(Q49886751)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29456084%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

title

Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene (English)

1 reference

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17 March 2020

0 references

1 reference

6

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17 March 2020

Denes Hnisz

7

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17 March 2020

Richard A. Young

14

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17 March 2020

15

Rudolf Jaenisch

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17 March 2020

8

Charles H Li

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17 March 2020

9

Bingbing Yuan

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17 March 2020

author name string

X Shawn Liu

1

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17 March 2020

Hao Wu

2

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17 March 2020

Marine Krzisch

3

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17 March 2020

John Graef

5

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17 March 2020

Chuanyun Xu

10

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17 March 2020

Dan Vershkov

12

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17 March 2020

Angela Cacace

13

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17 March 2020

Xuebing Wu

4

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17 March 2020

Yun Li

11

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17 March 2020

language of work or name

English

0 references

publication date

15 February 2018

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17 March 2020

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17 March 2020

volume

172

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17 March 2020

issue

5

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17 March 2020

page(s)

979-992.e6

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describes a project that uses

17 March 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6375087/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

1 reference

12 December 2020

Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium

1 reference

12 December 2020

Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits

1 reference

12 December 2020

Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells.

1 reference

12 December 2020

Dendritic spine structural anomalies in fragile-X mental retardation syndrome

1 reference

12 December 2020

Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X.

1 reference

12 December 2020

Altered synaptic plasticity in a mouse model of fragile X mental retardation

1 reference

12 December 2020

Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome

1 reference

12 December 2020

Repeat instability: mechanisms of dynamic mutations

1 reference

12 December 2020

Fmr1 KO mice as a possible model of autistic features.

1 reference

12 December 2020

FMR1 RNA within the intranuclear inclusions of fragile X-associated tremor/ataxia syndrome (FXTAS).

1 reference

12 December 2020

Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice

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12 December 2020

Correction of fragile X syndrome in mice.

1 reference

12 December 2020

Developmental study of fragile X syndrome using human embryonic stem cells derived from preimplantation genetically diagnosed embryos

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12 December 2020

Model-based analysis of ChIP-Seq (MACS)

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12 December 2020

Advances in the treatment of fragile X syndrome

1 reference

12 December 2020

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

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12 December 2020

Fragile X mental retardation protein replacement restores hippocampal synaptic function in a mouse model of fragile X syndrome

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12 December 2020

Human DNA methylomes at base resolution show widespread epigenomic differences

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12 December 2020

Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells

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12 December 2020

Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications.

1 reference

12 December 2020

Cellular toxicity of expanded RNA repeats: focus on RNA foci

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12 December 2020

FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism

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12 December 2020

Molecular mechanisms of fragile X syndrome: a twenty-year perspective

1 reference

12 December 2020

Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice

1 reference

12 December 2020

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

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12 December 2020

STAR: ultrafast universal RNA-seq aligner

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12 December 2020

Multiplex genome engineering using CRISPR/Cas systems

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12 December 2020

RNA-guided human genome engineering via Cas9

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12 December 2020

The unstable repeats--three evolving faces of neurological disease

1 reference

12 December 2020

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.

1 reference

12 December 2020

The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote

1 reference

12 December 2020

Fragile X mental retardation protein and synaptic plasticity

1 reference

12 December 2020

CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome

1 reference

12 December 2020

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

1 reference

12 December 2020

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

1 reference

12 December 2020

Rapid single-step induction of functional neurons from human pluripotent stem cells

1 reference

12 December 2020

Global epigenomic reconfiguration during mammalian brain development

1 reference

12 December 2020

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

1 reference

12 December 2020

Reversing DNA methylation: mechanisms, genomics, and biological functions

1 reference

12 December 2020

Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome

1 reference

12 December 2020

Fragile X mental retardation protein regulates synaptic and behavioral plasticity to repeated cocaine administration

1 reference

12 December 2020

Reduced phenotypic severity following adeno-associated virus-mediated Fmr1 gene delivery in fragile X mice.

1 reference

12 December 2020

Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome

1 reference

12 December 2020

The Autism Spectrum Disorders Stem Cell Resource at Children's Hospital of Orange County: Implications for Disease Modeling and Drug Discovery

1 reference

12 December 2020

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

1 reference

12 December 2020

Epigenetic characterization of the FMR1 promoter in induced pluripotent stem cells from human fibroblasts carrying an unmethylated full mutation

1 reference

12 December 2020

FMR1 epigenetic silencing commonly occurs in undifferentiated fragile X-affected embryonic stem cells

1 reference

12 December 2020

A competitive advantage by neonatally engrafted human glial progenitors yields mice whose brains are chimeric for human glia

1 reference

12 December 2020

Molecular mechanisms regulating the defects in fragile X syndrome neurons derived from human pluripotent stem cells

1 reference

12 December 2020

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

1 reference

12 December 2020

Clinical, molecular, and pharmacological aspects of FMR1 related disorders

1 reference

12 December 2020

Human body epigenome maps reveal noncanonical DNA methylation variation

1 reference

12 December 2020

Functional Correction of Large Factor VIII Gene Chromosomal Inversions in Hemophilia A Patient-Derived iPSCs Using CRISPR-Cas9.

1 reference

12 December 2020

Altered Neuronal and Circuit Excitability in Fragile X Syndrome.

1 reference

12 December 2020

Reversion of FMR1 Methylation and Silencing by Editing the Triplet Repeats in Fragile X iPSC-Derived Neurons.

1 reference

12 December 2020

Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy.

1 reference

12 December 2020

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.

1 reference

12 December 2020

In vivo gene editing in dystrophic mouse muscle and muscle stem cells

1 reference

12 December 2020

Repurposing the CRISPR-Cas9 system for targeted DNA methylation

1 reference

12 December 2020

CGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic Proteins

1 reference

12 December 2020

CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter.

1 reference

12 December 2020

Sustained expression of FMR1 mRNA from reactivated fragile X syndrome alleles after treatment with small molecules that prevent trimethylation of H3K27.

1 reference

12 December 2020

A CRISPR-based approach for targeted DNA demethylation

1 reference

12 December 2020

Transcriptional Reactivation of the FMR1 Gene. A Possible Approach to the Treatment of the Fragile X Syndrome

1 reference

12 December 2020

Editing DNA Methylation in the Mammalian Genome

1 reference

12 December 2020

Reactivation of FMR1 by CRISPR/Cas9-Mediated Deletion of the Expanded CGG-Repeat of the Fragile X Chromosome.

1 reference

12 December 2020

CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

1 reference

12 December 2020

Inhibition of CRISPR-Cas9 with Bacteriophage Proteins

1 reference

12 December 2020

CRISPR/Cas9-mediated somatic and germline gene correction to restore hemostasis in hemophilia B mice.

1 reference

12 December 2020

Fragile X targeted pharmacotherapy: lessons learned and future directions

1 reference

12 December 2020

10.1016/J.CELL.2018.01.012

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29456084%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

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17 March 2020

PubMed publication ID

29456084

1 reference