(Q50042411)

English

Effect of Single Nucleotide Polymorphisms in the Xenobiotic-sensing Receptors NR1I2 and NR1I3 on the Pharmacokinetics and Toxicity of Irinotecan in Colorectal Cancer Patients.

scientific article published on 26 April 2016

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

23 February 2018

http://europepmc.org/abstract/MED/27116457

Effect of Single Nucleotide Polymorphisms in the Xenobiotic-sensing Receptors NR1I2 and NR1I3 on the Pharmacokinetics and Toxicity of Irinotecan in Colorectal Cancer Patients. (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 February 2018

http://europepmc.org/abstract/MED/27116457

colorectal cancer

1 reference

based on heuristic

inferred from title

single-nucleotide polymorphism

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

Nicole Tubiana Mathieu

8

1 reference

Europe PubMed Central

PubMed publication ID

23 February 2018

http://europepmc.org/abstract/MED/27116457

object named as

Marc Ychou

3

0 references

object named as

Jacques Robert

2

0 references

author name string

Litaty Céphanoée Mbatchi

1

1 reference

Europe PubMed Central

PubMed publication ID

23 February 2018

http://europepmc.org/abstract/MED/27116457

Jean-Christophe Boyer

4

1 reference

Europe PubMed Central

PubMed publication ID

23 February 2018

http://europepmc.org/abstract/MED/27116457

Maguy Del Rio

5

1 reference

Europe PubMed Central

PubMed publication ID

23 February 2018

http://europepmc.org/abstract/MED/27116457

Matthieu Gassiot

6

1 reference

Europe PubMed Central

PubMed publication ID

23 February 2018

http://europepmc.org/abstract/MED/27116457

Fabienne Thomas

7

1 reference

Europe PubMed Central

PubMed publication ID

23 February 2018

http://europepmc.org/abstract/MED/27116457

Alexandre Evrard

9

1 reference

Europe PubMed Central

PubMed publication ID

23 February 2018

http://europepmc.org/abstract/MED/27116457

publication date

26 April 2016

1 reference

Europe PubMed Central

PubMed publication ID

23 February 2018

http://europepmc.org/abstract/MED/27116457

Clinical Pharmacokinetics

1 reference

Europe PubMed Central

PubMed publication ID

23 February 2018

http://europepmc.org/abstract/MED/27116457

55

1 reference

Europe PubMed Central

PubMed publication ID

23 February 2018

http://europepmc.org/abstract/MED/27116457

9

1 reference

Europe PubMed Central

PubMed publication ID

23 February 2018

http://europepmc.org/abstract/MED/27116457

1145-1157

1 reference

Europe PubMed Central

PubMed publication ID

23 February 2018

http://europepmc.org/abstract/MED/27116457

https://scigraph.springernature.com/pub.10.1007/s40262-016-0392-5

0 references

Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group

1 reference

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21 January 2018

Tritherapy with fluorouracil/leucovorin, irinotecan and oxaliplatin (FOLFIRINOX): a phase II study in colorectal cancer patients with non-resectable liver metastases.

1 reference

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21 January 2018

Dose-finding and pharmacokinetic study to optimize the dosing of irinotecan according to the UGT1A1 genotype of patients with cancer

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21 January 2018

Pharmacogenetics of irinotecan metabolism and transport: an update

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21 January 2018

FOLFOX/FOLFIRI pharmacogenetics: the call for a personalized approach in colorectal cancer therapy

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21 January 2018

Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?

1 reference

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21 January 2018

Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.

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21 January 2018

Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Nuclear-receptor-mediated regulation of drug- and bile-acid-transporter proteins in gut and liver

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https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism

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21 January 2018

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

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https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Nuclear receptor-mediated regulation of carboxylesterase expression and activity

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Genetic polymorphisms of drug metabolizing enzymes and transporters: the long way from bench to bedside

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Effects of St. John's wort on irinotecan metabolism

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Identification of polymorphisms in the 3'-untranslated region of the human pregnane X receptor (PXR) gene associated with variability in cytochrome P450 3A (CYP3A) metabolism

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

PXR pharmacogenetics: association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast cancer patients

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Population pharmacokinetic modeling of the association between 63396C->T pregnane X receptor polymorphism and unboosted atazanavir clearance

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C-->T) with reduced concentrations of unboosted atazanavir

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Pazopanib efficacy in renal cell carcinoma: evidence for predictive genetic markers in angiogenesis-related and exposure-related genes.

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Polymorphisms in SLCO1B3 and NR1I2 as genetic determinants of hematotoxicity of carboplatin and paclitaxel combination.

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Sensitive HPLC-Fluorescence Method for Irinotecan and Four Major Metabolites in Human Plasma and Saliva: Application to Pharmacokinetic Studies

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Tacrolimus population pharmacokinetic-pharmacogenetic analysis and Bayesian estimation in renal transplant recipients

1 reference

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21 January 2018

The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

The potential of steroids and xenobiotic receptor polymorphisms in forecasting cyclosporine pharmacokinetic variability in young kidney transplant recipients

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Association of a single nucleotide polymorphism in the constitutive androstane receptor gene with bone mineral density

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Combined effects of hepatocyte nuclear factor 4α and constitutive androstane receptor on stable warfarin doses

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens.

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Investigation of associations between the pregnane-X receptor gene (NR1I2) and Crohn's disease in Canadian children using a gene-wide haplotype-based approach

1 reference

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21 January 2018

Irinotecan pharmacogenomics

1 reference

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21 January 2018

Irinogenetics: how many stars are there in the sky?

1 reference

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21 January 2018

Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Clinical validity of new genetic biomarkers of irinotecan neutropenia: an independent replication study.

1 reference

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21 January 2018

UGT1A1 genotype and irinotecan therapy: general review and implementation in routine practice.

1 reference

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21 January 2018

SLCO1B1 and SLC19A1 gene variants and irinotecan-induced rapid response and survival: a prospective multicenter pharmacogenetics study of metastatic colorectal cancer

1 reference

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21 January 2018

Pharmacogenetics of ABC and SLC transporters in metastatic colorectal cancer patients receiving first-line FOLFIRI treatment.

1 reference

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21 January 2018

A population pharmacokinetic-pharmacogenetic analysis of atazanavir

1 reference

https://api.crossref.org/works/10.1007%2FS40262-016-0392-5

21 January 2018

Successful pharmacogenetics-based optimization of unboosted atazanavir plasma exposure in HIV-positive patients: a randomized, controlled, pilot study (the REYAGEN study).

1 reference

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SNPassoc: an R package to perform whole genome association studies

1 reference

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Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).

1 reference

https://pubmed.ncbi.nlm.nih.gov/27116457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel UGT1 marker associated with better tolerance against irinotecan-induced severe neutropenia in metastatic colorectal cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/27116457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic polymorphisms associated with a prolonged progression-free survival in patients with metastatic renal cell cancer treated with sunitinib

1 reference

https://pubmed.ncbi.nlm.nih.gov/27116457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered irinotecan pharmacokinetics in pediatric high-grade glioma patients receiving enzyme-inducing anticonvulsant therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27116457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea

1 reference

https://pubmed.ncbi.nlm.nih.gov/27116457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A limited sampling strategy to estimate the pharmacokinetic parameters of irinotecan and its active metabolite, SN-38, in patients with metastatic digestive cancer receiving the FOLFIRI regimen

1 reference

https://pubmed.ncbi.nlm.nih.gov/27116457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27116457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan

1 reference

https://pubmed.ncbi.nlm.nih.gov/27116457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human Pregnane X Receptor Genotype of the Donor but Not of the Recipient Is a Risk Factor for Delayed Graft Function After Renal Transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/27116457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The false discovery rate: a key concept in large-scale genetic studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27116457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters

1 reference

https://pubmed.ncbi.nlm.nih.gov/27116457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase I study of UGT1A1 *28/*6 genotype-directed dosing of irinotecan (CPT-11) in Korean patients with metastatic colorectal cancer receiving FOLFIRI

1 reference

https://pubmed.ncbi.nlm.nih.gov/27116457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sudden death related to toxicity in a patient on capecitabine and irinotecan plus bevacizumab intake: pharmacogenetic implications.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27116457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S40262-016-0392-5

1 reference

Europe PubMed Central

PubMed publication ID

23 February 2018

http://europepmc.org/abstract/MED/27116457

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 February 2018

http://europepmc.org/abstract/MED/27116457

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