(Q50042580)

English

Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein.

scientific article published on 16 January 2018

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

phosphorylation

1 reference

based on heuristic

inferred from title

invasive ductal carcinoma

1 reference

based on heuristic

inferred from title

pancreatic ductal adenocarcinoma

1 reference

based on heuristic

inferred from title

pancreatic ductal carcinoma

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

author name string

Yi-Chieh Yang

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Hsiu-Po Wang

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Chia-Tung Shun

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Hsin-Yi Huang

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Kuo-Tai Hua

8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

language of work or name

0 references

publication date

16 January 2018

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

37

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

13

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1730-1742

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

https://scigraph.springernature.com/pub.10.1038/s41388-017-0086-y

0 references

Understanding the Warburg effect: the metabolic requirements of cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Multimolecular forms of pyruvate kinase from rat and other mammalian tissues. I. Electrophoretic studies.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

PKM2 regulates chromosome segregation and mitosis progression of tumor cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Cytosolic PKM2 stabilizes mutant EGFR protein expression through regulating HSP90-EGFR association.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system: evidence from 16 cohort studies

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Pyruvate Kinase Muscle Isoenzyme 2 (PKM2) Expression Is Associated with Overall Survival in Pancreatic Ductal Adenocarcinoma

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

PAK signalling during the development and progression of cancer

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Comparison of plasma Tu-M2-PK and CA19-9 in pancreatic cancer.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Diagnostic and prognostic value of plasma tumor M2 pyruvate kinase in periampullary cancer: evidence for a novel biological marker of adverse prognosis.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

The combination of the expression of hexokinase 2 and pyruvate kinase M2 is a prognostic marker in patients with pancreatic cancer

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

PKM2 Promotes Cell Survival and Invasion Under Metabolic Stress by Enhancing Warburg Effect in Pancreatic Ductal Adenocarcinoma

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

The HSP90 chaperone machinery.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

GP73 N-glycosylation at Asn144 reduces hepatocellular carcinoma cell motility and invasiveness

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

The Integrated Role of Wnt/β-Catenin, N-Glycosylation, and E-Cadherin-Mediated Adhesion in Network Dynamics

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Lack of Evidence for PKM2 Protein Kinase Activity

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Structure, biochemistry, and biology of PAK kinases

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Tumor M2-Pyruvate Kinase as Tumor Marker in Exocrine Pancreatic Cancer A Meta-Analysis

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Isoform switch of pyruvate kinase M1 indeed occurs but not to pyruvate kinase M2 in human tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Pyruvate kinase M2 (PKM2) expression correlates with prognosis in solid cancers: a meta-analysis

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Heat shock proteins are differentially expressed in human gastrointestinal cancers.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of M2-type pyruvate kinase from human meningioma by allosteric effectors fructose 1,6 diphosphate and L-alanine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29335522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing

1 reference

https://pubmed.ncbi.nlm.nih.gov/29335522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The multifaceted regulation and functions of PKM2 in tumor progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/29335522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/S41388-017-0086-Y

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q50042580&oldid=1587539185"