(Q50085603)

English

PXR, CAR and HNF4alpha genotypes and their association with pharmacokinetics and pharmacodynamics of docetaxel and doxorubicin in Asian patients.

scientific article published on 18 September 2007

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scholarly article

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

PXR, CAR and HNF4alpha genotypes and their association with pharmacokinetics and pharmacodynamics of docetaxel and doxorubicin in Asian patients. (English)

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

1 reference

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pharmacokinetics

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based on heuristic

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pharmacodynamics

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author name string

S Y Hor

1

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Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

S C Lee

2

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Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

C I Wong

3

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Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

Y W Lim

4

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

R C Lim

5

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Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

L Z Wang

6

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

L Fan

7

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Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

J Y Guo

8

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

H S Lee

9

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

B C Goh

10

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Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

T Tan

11

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http://europepmc.org/abstract/MED/17876342

publication date

18 September 2007

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Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

The Pharmacogenomics Journal

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24 February 2018

http://europepmc.org/abstract/MED/17876342

8

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Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

2

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Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

139-146

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Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

https://scigraph.springernature.com/pub.10.1038/sj.tpj.6500478

0 references

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Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies

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The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

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PXR, CAR and drug metabolism

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The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

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The DNA binding domain of hepatocyte nuclear factor 4 mediates cooperative, specific binding to DNA and heterodimerization with the retinoid X receptor alpha

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Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting.

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Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degree

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Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics

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Clinical pharmacokinetics of docetaxel.

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The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

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Screening for polymorphisms in the PXR gene in a Dutch population.

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Eleven Novel Single Nucleotide Polymorphisms in the NRH2 (PXR) Gene, Pour of which Induce Non-synonymous Amino Acid Alterations

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Interethnic variability of warfarin maintenance requirement is explained by VKORC1 genotype in an Asian population

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The functional Thr130Ile and Val255Met polymorphisms of the hepatocyte nuclear factor-4alpha (HNF4A): gene associations with type 2 diabetes or altered beta-cell function among Danes.

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Critical structural elements and multitarget protein interactions of the transcriptional activator AF-1 of hepatocyte nuclear factor 4.

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Maturity-onset diabetes of the young Type 1 (MODY1)-associated mutations R154X and E276Q in hepatocyte nuclear factor 4alpha (HNF4alpha) gene impair recruitment of p300, a key transcriptional co-activator

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Hepatocyte nuclear factor 4 alpha isoforms originated from the P1 promoter are expressed in human pancreatic beta-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms.

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21 January 2018

The activation function-1 of hepatocyte nuclear factor-4 is an acidic activator that mediates interactions through bulky hydrophobic residues

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21 January 2018

Quantification of docetaxel and its main metabolites in human plasma by liquid chromatography/tandem mass spectrometry

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21 January 2018

Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method

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Genetic epidemiology of MODY in the Czech republic: new mutations in the MODY genes HNF-4alpha, GCK and HNF-1alpha

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T130I mutation in HNF-4alpha gene is a loss-of-function mutation in hepatocytes and is associated with late-onset Type 2 diabetes mellitus in Japanese subjects

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Pharmacogenetic screening of CYP3A and ABCB1 in relation to population pharmacokinetics of docetaxel

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A sensitive and simple high-performance liquid chromatographic method for the determination of doxorubicin and its metabolites in plasma

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Identifiers

10.1038/SJ.TPJ.6500478

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17876342

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