(Q35164664)

6 August 2017

1 reference

title

Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs (English)

1 reference

6 August 2017

1 reference

Toshiyuki Sakaeda

1

1 reference

PubMed ID

12831320

6 August 2017

Tsutomu Nakamura

series ordinal

2

1 reference

PubMed ID

12831320

6 August 2017

Katsuhiko Okumura

series ordinal

3

1 reference

6 August 2017

1 July 2003

1 reference

6 August 2017

1 reference

6 August 2017

4

1 reference

6 August 2017

397-410

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6 August 2017

4

1 reference

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

6 August 2017

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Is the multidrug transporter a flippase?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Role of P-glycoprotein in drug disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

The human ATP-binding cassette (ABC) transporter superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

P-Glycoprotein in clinical cardiology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Progress in understanding the structure-activity relationships of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Investigation of the coordinated functional activities of cytochrome P450 3A4 and P-glycoprotein in limiting the absorption of xenobiotics in Caco-2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Simvastatin and lovastatin, but not pravastatin, interact with MDR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Interaction of digoxin with antihypertensive drugs via MDR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Structure and expression of the human MDR (P-glycoprotein) gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Identification of functionally variant MDR1 alleles among European Americans and African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Frequency of C3435T polymorphism of MDR1 gene in African people

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Frequency distribution of C3435T mutation in exon 26 of the MDR1 gene in a Spanish population

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Expression polymorphism of the blood-brain barrier component P-glycoprotein (MDR1) in relation to Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

The MDR1 polymorphisms at exons 21 and 26 predict steroid weaning in pediatric heart transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Dipyridamole enhances digoxin bioavailability via P-glycoprotein inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

MDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

C3435T mutation in exon 26 of the human MDR1 gene and cyclosporine pharmacokinetics in healthy subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Multidrug resistance in human tumors--molecular diagnosis and clinical significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Cancer multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Experimental reversal of P-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Search for specific inhibitors of multidrug resistance in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Helicobacter bilis infection accelerates and H. hepaticus infection delays the development of colitis in multiple drug resistance-deficient (mdr1a-/-) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Multiple physiological functions for multidrug transporter P-glycoprotein?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

MDR1 genotype-related pharmacokinetics and pharmacodynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Digoxin up-regulates multidrug resistance transporter (MDR1) mRNA and simultaneously down-regulates steroid xenobiotic receptor mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Pharmacogenomics--drug disposition, drug targets, and side effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

The barrier function of CYP3A4 and P-glycoprotein in the small bowel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Point mutations in the mdr1 promoter of human osteosarcomas are associated with in vitro responsiveness to multidrug resistance relevant drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677: functional relevance to pharmacokinetics of digoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Effects of polymorphisms of MDR1, MRP1, and MRP2 genes on their mRNA expression levels in duodenal enterocytes of healthy Japanese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Human MDR1 polymorphism: G2677T/A and C3435T have no effect on MDR1 transport activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

MDR1 genotype-related duodenal absorption rate of digoxin in healthy Japanese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Digoxin up-regulates MDR1 in human colon carcinoma Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

MDR1 up-regulated by apoptotic stimuli suppresses apoptotic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

Simultaneous genotyping of seven single-nucleotide polymorphisms in the MDR1 gene by single-tube multiplex minisequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.4.397.22747

10.1517/PHGS.4.4.397.22747

21 January 2018

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12831320