(Q50086566)

24 February 2018

title

Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John's wort. (English)

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24 February 2018

author

Olaf Kelber

4

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24 February 2018

author name string

Ute Gödtel-Armbrust

1

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24 February 2018

Annegret Metzger

2

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24 February 2018

Ulrike Kroll

3

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24 February 2018

Leszek Wojnowski

5

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24 February 2018

publication date

26 June 2007

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24 February 2018

Naunyn-Schmiedeberg's Archives of Pharmacology

published in

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24 February 2018

volume

375

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24 February 2018

page(s)

377-382

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24 February 2018

issue

6

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24 February 2018

https://scigraph.springernature.com/pub.10.1007/s00210-007-0172-8

exact match

0 references

cites work

The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer

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Crossref

https://api.crossref.org/works/10.1007%2FS00210-007-0172-8

The extent of induction of CYP3A by St. John's wort varies among products and is linked to hyperforin dose.

21 January 2018

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12 December 2020

Comparison of German St. John's wort products according to hyperforin and total hypericin content.

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Pharmacokinetic interactions of drugs with St John's wort

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St John's Wort for depression

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Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.

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In vitro interaction of the HIV protease inhibitor ritonavir with herbal constituents: changes in P-gp and CYP3A4 activity

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St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

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Human colonic adenocarcinoma cells. I. Establishment and description of a new line

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12 December 2020

Role of hyperforin in the pharmacological activities of St. John's Wort.

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12 December 2020

Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.

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12 December 2020

Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7.

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12 December 2020

Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures

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12 December 2020

Acute heart transplant rejection due to Saint John's wort

1 reference

12 December 2020

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

1 reference

12 December 2020

Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.

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12 December 2020

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

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12 December 2020

Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients

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12 December 2020

Hypericum perforatum: which constituents may induce intestinal MDR1 and CYP3A4 mRNA expression?

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12 December 2020

St John's wort (Hypericum perforatum): drug interactions and clinical outcomes

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12 December 2020

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

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12 December 2020

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

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12 December 2020

MDR- and CYP3A4-mediated drug-herbal interactions

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12 December 2020

Indinavir concentrations and St John's wort.

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12 December 2020

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine

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12 December 2020

10.1007/S00210-007-0172-8

Identifiers

DOI

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24 February 2018

PubMed ID

17593354

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24 February 2018