(Q50295876)

English

Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-927830)

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Statements

1 reference

8 July 2022

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-927830

1 reference

8 July 2022

mRNA Cleaved by SMG6 [cytosol]

quantity

1

object of statement has role

1 reference

8 July 2022

Cap Binding Complex (CBC) [cytosol]

quantity

1

object of statement has role

1 reference

8 July 2022

Eukaryotic translation initiation factor 4 gamma 1

quantity

1

object of statement has role

1 reference

8 July 2022

Poly(A) binding protein cytoplasmic 1

quantity

1

object of statement has role

1 reference

8 July 2022

PP2A (Aalpha:B55alpha:Calpha) [cytosol]

quantity

1

object of statement has role

1 reference

8 July 2022

SMG5 nonsense mediated mRNA decay factor

quantity

1

object of statement has role

1 reference

8 July 2022

SMG6 nonsense mediated mRNA decay factor

quantity

1

object of statement has role

1 reference

8 July 2022

SMG7 nonsense mediated mRNA decay factor

quantity

1

object of statement has role

1 reference

8 July 2022

UPF1 RNA helicase and ATPase

quantity

1

object of statement has role

1 reference

8 July 2022

1

object of statement has role

1 reference

8 July 2022

PP2A (Aalpha:B55alpha:Calpha) [cytosol]

quantity

1

object of statement has role

1 reference

8 July 2022

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

1 reference

8 July 2022

How and where are nonsense mRNAs degraded in mammalian cells?

1 reference

8 July 2022

Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities

1 reference

8 July 2022

Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover

1 reference

8 July 2022

Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay

1 reference

8 July 2022

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

1 reference

8 July 2022

Premature termination codons enhance mRNA decapping in human cells.

1 reference

8 July 2022

Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.

1 reference

8 July 2022

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

1 reference

8 July 2022

Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay

1 reference

8 July 2022

Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway

1 reference

8 July 2022

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

1 reference

8 July 2022

SMG7 acts as a molecular link between mRNA surveillance and mRNA decay

1 reference

8 July 2022

Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q50295876)

Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex

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