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Thrombin proteolyzes IGF:IGFBP3:ALS
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-381446)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-381446
part of
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-381446
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-381446
exact match
https://identifiers.org/reactome:R-HSA-381446
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-381446
has part(s)
IGF:IGFBP3:ALS [extracellular region]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-381446
IGF1,2 [extracellular region]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-381446
Insulin like growth factor binding protein acid labile subunit
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-381446
Insulin like growth factor binding protein 3
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-381446
activated thrombin (factor IIa) [extracellular region]
quantity
1
object has role
modifier
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-381446
cites work
IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-381446
Cellular actions of the insulin-like growth factor binding proteins
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-381446
IGFBP-3 binding to endothelial cells inhibits plasmin and thrombin proteolysis
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-381446
Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-381446
The role of insulin-like growth factor binding proteins.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-381446
Identifiers
Reactome ID
R-HSA-381446
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-381446
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