(Q50332286)

English

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy.

scientific article published on 21 February 2018

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17 March 2020

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy (English)

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17 March 2020

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Sridhar Nimmagadda

11

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17 March 2020

Piotr T Wysocki

9

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17 March 2020

Luigi Marchionni

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17 March 2020

David Sidransky

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David Sidransky

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17 March 2020

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Rajani Ravi

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17 March 2020

Kimberly A Noonan

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17 March 2020

Vui Pham

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17 March 2020

Rishi Bedi

4

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17 March 2020

Ivan V Ozerov

6

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17 March 2020

Eugene Makarev

7

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17 March 2020

Artem V Artemov

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17 March 2020

Ranee Mehra

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17 March 2020

Ivan M Borrello

14

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17 March 2020

Evgeny Izumchenko

15

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17 March 2020

Atul Bedi

16

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17 March 2020

Alex Zhavoronkov

5

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17 March 2020

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21 February 2018

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17 March 2020

Nature Communications

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17 March 2020

9

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17 March 2020

1

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17 March 2020

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17 March 2020

copyright license

Creative Commons Attribution 4.0 International

21 February 2018

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April 2022 Public Data File from Crossref

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https://scigraph.springernature.com/pub.10.1038/s41467-017-02696-6

0 references

In silico analysis of pathways activation landscape in oral squamous cell carcinoma and oral leukoplakia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Adaptive Immune Resistance: How Cancer Protects from Immune Attack

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Adoptive transfer of activated marrow-infiltrating lymphocytes induces measurable antitumor immunity in the bone marrow in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Nivolumab and ipilimumab versus ipilimumab in untreated melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Immune checkpoint blockade: a common denominator approach to cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Immune Checkpoint Blockade in Cancer Therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

The roles of TGFβ in the tumour microenvironment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Inhibition of TGF-β1 signaling promotes central memory T cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

TGFβ signalling in context

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Tumor Immunotherapy Directed at PD-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

The blockade of immune checkpoints in cancer immunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

The immune contexture in human tumours: impact on clinical outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Tumor microenvironments direct the recruitment and expansion of human Th17 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Plasticity of CD4+ T cell lineage differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Mechanisms of foxp3+ T regulatory cell-mediated suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Control of regulatory T cell lineage commitment and maintenance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Tumor regulatory T cells potently abrogate antitumor immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

CTLA-4 control over Foxp3+ regulatory T cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

TGF-beta: a master of all T cell trades

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

TGFbeta in Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Regulatory T cells and immune tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Regulatory T cells and treatment of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Regulatory T cells, transforming growth factor-beta, and immune suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Tumor evasion of the immune system by converting CD4+CD25- T cells into CD4+CD25+ T regulatory cells: role of tumor-derived TGF-beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Immunostimulatory monoclonal antibodies for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Cancer despite immunosurveillance: immunoselection and immunosubversion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

TGF-beta-mediated suppression by CD4+CD25+ T cells is facilitated by CTLA-4 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Transforming growth factor-beta induces development of the T(H)17 lineage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Regulatory T cells, tumour immunity and immunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Transforming growth factor-beta regulation of immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Regulatory T cells in immune surveillance and treatment of cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

The therapeutic implications of intratumoral regulatory T cells

1 reference

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22 May 2018

The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice

1 reference

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22 May 2018

TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

1 reference

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22 May 2018

Mechanisms of suppression by suppressor T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Immunosuppressive networks in the tumour environment and their therapeutic relevance

1 reference

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22 May 2018

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo

1 reference

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22 May 2018

Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity

1 reference

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22 May 2018

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

1 reference

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22 May 2018

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

1 reference

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22 May 2018

Control of regulatory T cell development by the transcription factor Foxp3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821872

22 May 2018

Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

1 reference

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22 May 2018

Merging two gene-expression studies via cross-platform normalization.

1 reference

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14 August 2018

Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function

1 reference

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14 August 2018

Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer

1 reference

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30 November 2018

Activated marrow-infiltrating lymphocytes effectively target plasma cells and their clonogenic precursors

1 reference

https://api.crossref.org/works/10.1038%2FS41467-017-02696-6

7 January 2021

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inferred from DOI database lookup

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10.1038/S41467-017-02696-6

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17 March 2020

2018NatCo...9..741R

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1 reference

Europe PubMed Central

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17 March 2020

1 reference

Europe PubMed Central

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17 March 2020

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