(Q50336994)

English

The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia.

scientific article published in October 2012

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia. (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

Victor L Ruiz-Perez

11

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

Judith A Goodship

10

object named as

Judith A Goodship

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

author name string

Jose A Caparrós-Martín

1

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

María Valencia

2

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

Edel Reytor

3

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

María Pacheco

4

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

Margarita Fernandez

5

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

Antonio Perez-Aytes

6

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

Esther Gean

7

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

Pablo Lapunzina

8

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

Heiko Peters

9

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

publication date

1 October 2012

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

Human Molecular Genetics

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

22

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Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

1

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

124-139

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

Mechanisms and functions of Hedgehog signalling across the metazoa

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Hedgehog signalling in the mouse requires intraflagellar transport proteins

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

The primary cilium: a signalling centre during vertebrate development

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Intraflagellar transport

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Cilia and Hedgehog responsiveness in the mouse

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Patched1 regulates hedgehog signaling at the primary cilium

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Mutations in two nonhomologous genes in a head-to-head configuration cause Ellis-van Creveld syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Widening the mutation spectrum of EVC and EVC2: ectopic expression of Weyer variants in NIH 3T3 fibroblasts disrupts Hedgehog signaling.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Long interspersed nuclear element-1 (LINE1)-mediated deletion of EVC, EVC2, C4orf6, and STK32B in Ellis-van Creveld syndrome with borderline intelligence.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

A novel heterozygous deletion in the EVC2 gene causes Weyers acrofacial dysostosis.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Evc works in chondrocytes and osteoblasts to regulate multiple aspects of growth plate development in the appendicular skeleton and cranial base.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Altered neural cell fates and medulloblastoma in mouse patched mutants

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Small molecule modulation of Smoothened activity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Divergence of hedgehog signal transduction mechanism between Drosophila and mammals

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Intraflagellar transport is essential for endochondral bone formation.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Prolyl 3-hydroxylase 1 and CRTAP are mutually stabilizing in the endoplasmic reticulum collagen prolyl 3-hydroxylation complex

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS409

21 January 2018

Identifiers

10.1093/HMG/DDS409

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/23026747

ResearchGate publication ID

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