(Q50545712)

15 March 2018

title

The differentiation stage of p53-Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development. (English)

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15 March 2018

main subject

mesenchymal stem cell

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4

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María L Toribio

7

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15 March 2018

Pablo Menendez

8

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15 March 2018

Rene Rodriguez

9

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author name string

R Rubio

1

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15 March 2018

I Gutierrez-Aranda

2

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15 March 2018

A I Sáez-Castillo

3

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M Rosu-Myles

5

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S Gonzalez-Garcia

6

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language of work or name

English

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publication date

10 December 2012

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15 March 2018

published in

Oncogene

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15 March 2018

volume

32

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15 March 2018

issue

41

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15 March 2018

page(s)

4970-4980

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15 March 2018

https://scigraph.springernature.com/pub.10.1038/onc.2012.507

exact match

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cites work

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Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

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Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice

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Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation.

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Osteosarcoma originates from mesenchymal stem cells in consequence of aneuploidization and genomic loss of Cdkn2.

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Sarcoma derived from cultured mesenchymal stem cells

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p53 regulates the proliferation, differentiation and spontaneous transformation of mesenchymal stem cells.

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FUS-CHOP fusion protein expression coupled to p53 deficiency induces liposarcoma in mouse but not in human adipose-derived mesenchymal stem/stromal cells.

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Loss of p53 induces tumorigenesis in p21-deficient mesenchymal stem cells

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Deficiency in p53 but not retinoblastoma induces the transformation of mesenchymal stem cells in vitro and initiates leiomyosarcoma in vivo.

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Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling

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Absence of the p53 tumor suppressor gene promotes osteogenesis in mesenchymal stem cells.

21 January 2018

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p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner

21 January 2018

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Rb regulates fate choice and lineage commitment in vivo

21 January 2018

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pRb: master of differentiation. Coupling irreversible cell cycle withdrawal with induction of muscle-specific transcription.

21 January 2018

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Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1-/- mice.

21 January 2018

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The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation

21 January 2018

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Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage

21 January 2018

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Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease

21 January 2018

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Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice

21 January 2018

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Osteosarcoma development and stem cell differentiation

21 January 2018

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A differentiation-based microRNA signature identifies leiomyosarcoma as a mesenchymal stem cell-related malignancy

21 January 2018

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Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency

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A spatially and temporally restricted mouse model of soft tissue sarcoma.

21 January 2018

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Conditional inactivation of Brca1, p53 and Rb in mouse ovaries results in the development of leiomyosarcomas

21 January 2018

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c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis.

21 January 2018

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Involvement of INK4A gene products in the pathogenesis and development of human osteosarcoma.

21 January 2018

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Deregulation of the G1 to S-phase cell cycle checkpoint is involved in the pathogenesis of human osteosarcoma.

21 January 2018

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Mesenchymal stem cells: revisiting history, concepts, and assays.

21 January 2018

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Enrichment of human ESC-derived multipotent mesenchymal stem cells with immunosuppressive and anti-inflammatory properties capable to protect against experimental inflammatory bowel disease.

21 January 2018

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Bone marrow mesenchymal stem cells from infants with MLL-AF4+ acute leukemia harbor and express the MLL-AF4 fusion gene

21 January 2018

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Human induced pluripotent stem cells develop teratoma more efficiently and faster than human embryonic stem cells regardless the site of injection

21 January 2018

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Molecular profiling of candidate human hematopoietic stem cells derived from human embryonic stem cells

21 January 2018

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The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells.

21 January 2018

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Multipotent mesenchymal stromal cells: clinical applications and cancer modeling

21 January 2018

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The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.507

Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor Suppressors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.507

Intra-bone marrow transplantation of human CD34(+) cells into NOD/LtSz-scid IL-2rgamma(null) mice permits multilineage engraftment without previous irradiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.507

Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.507

Influence of the different CD34+ and CD34- cell subsets infused on clinical outcome after non-myeloablative allogeneic peripheral blood transplantation from human leucocyte antigen-identical sibling donors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.507

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.507

1 reference

15 March 2018

PubMed ID

23222711

1 reference

15 March 2018