(Q50655181)

17 March 2018

title

The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells. (English)

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17 March 2018

author name string

Shinya Tanaka

1

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17 March 2018

Yasutaka Motomura

2

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17 March 2018

Yoshie Suzuki

3

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17 March 2018

Ryoji Yagi

4

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17 March 2018

Hiromasa Inoue

5

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17 March 2018

Shoichiro Miyatake

6

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17 March 2018

Masato Kubo

7

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17 March 2018

language of work or name

English

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publication date

5 December 2010

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17 March 2018

published in

Nature Immunology

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17 March 2018

volume

12

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17 March 2018

issue

1

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17 March 2018

page(s)

77-85

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17 March 2018

Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells

cites work

1 reference

12 December 2020

A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells

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12 December 2020

A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer

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12 December 2020

Interleukin-13 gene expression is regulated by GATA-3 in T cells: role of a critical association of a GATA and two GATG motifs

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12 December 2020

Regulation of the Th2 cytokine locus by a locus control region

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12 December 2020

PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer

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12 December 2020

Activation of the Interleukin-5 Promoter by cAMP in Murine EL-4 Cells Requires the GATA-3 and CLE0 Elements

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12 December 2020

Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus

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12 December 2020

Interchromosomal associations between alternatively expressed loci

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12 December 2020

Generation and analysis of interleukin-4 deficient mice

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12 December 2020

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12 December 2020

Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3.

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12 December 2020

Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation

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12 December 2020

Chromatin landscape dynamics of the Il4-Il13 locus during T helper 1 and 2 development

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12 December 2020

Cutting edge: the differential involvement of the N-finger of GATA-3 in chromatin remodeling and transactivation during Th2 development

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12 December 2020

The complex language of chromatin regulation during transcription

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12 December 2020

Long-range intrachromosomal interactions in the T helper type 2 cytokine locus

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12 December 2020

Regulation of the Il4 gene is independently controlled by proximal and distal 3' enhancers in mast cells and basophils

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12 December 2020

Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

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12 December 2020

Deletion of a coordinate regulator of type 2 cytokine expression in mice

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12 December 2020

A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmission.

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12 December 2020

GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

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12 December 2020

TH17 cells in development: an updated view of their molecular identity and genetic programming

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12 December 2020

Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation

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12 December 2020

Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses.

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12 December 2020

The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells.

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12 December 2020

Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region

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12 December 2020

Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo

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12 December 2020

SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses

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12 December 2020

GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells

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12 December 2020

Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci

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12 December 2020

Epigenetic control of T-helper-cell differentiation

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12 December 2020

Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level

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12 December 2020

A critical control element for interleukin-4 memory expression in T helper lymphocytes

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12 December 2020

Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene.

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12 December 2020

T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes.

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12 December 2020

The lineage decisions of helper T cells

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12 December 2020

Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization.

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12 December 2020

Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

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12 December 2020

How are T(H)1 and T(H)2 effector cells made?

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12 December 2020

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

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12 December 2020

The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3

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12 December 2020

GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels

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12 December 2020

Regulation of Th2 differentiation and Il4 locus accessibility.

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12 December 2020

Basal chromatin modification at the IL-4 gene in helper T cells

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12 December 2020

Notch directly regulates Gata3 expression during T helper 2 cell differentiation

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12 December 2020

Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons

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12 December 2020

Differentiation of effector CD4 T cell populations (*)

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12 December 2020

Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions

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12 December 2020

Replication initiation from a novel origin identified in the Th2 cytokine cluster locus requires a distant conserved noncoding sequence

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12 December 2020

Identifiers

DOI

10.1038/NI.1966

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17 March 2018

PubMed ID

21131966

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17 March 2018