(Q50665673)

17 March 2018

title

The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants. (English)

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17 March 2018

Eugenio Notomista

6

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Alberto Di Donato

object named as

Alberto Di Donato

5

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Antonello Merlino

object named as

Antonello Merlino

1

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author name string

Lelio Mazzarella

2

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17 March 2018

Anna Carannante

3

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17 March 2018

Anna Di Fiore

4

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17 March 2018

Filomena Sica

7

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17 March 2018

language of work or name

English

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publication date

22 February 2005

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17 March 2018

Journal of Biological Chemistry

published in

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17 March 2018

volume

280

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17 March 2018

issue

18

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17 March 2018

page(s)

17953-17960

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17 March 2018

https://api.crossref.org/works/10.1074%2FJBC.M501339200

1 reference

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Role of the N terminus in RNase A homologues: differences in catalytic activity, ribonuclease inhibitor interaction and cytotoxicity.

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Onconase: an unusually stable protein.

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Contribution of chain termini to the conformational stability and biological activity of onconase.

21 January 2018

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Global and local motions in ribonuclease A: a molecular dynamics study.

21 January 2018

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Reversible substrate-induced domain motions in ribonuclease A

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Contribution of active-site residues to the function of onconase, a ribonuclease with antitumoral activity

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Dynamic properties of the N-terminal swapped dimer of ribonuclease A.

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Effects of temperature on protein structure and dynamics: X-ray crystallographic studies of the protein ribonuclease-A at nine different temperatures from 98 to 320 K.

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Protein titration in the crystal state.

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Productive and nonproductive binding to ribonuclease A: X-ray structure of two complexes with uridylyl(2′,5′)guanosine

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The ultrahigh resolution crystal structure of ribonuclease A containing an isoaspartyl residue: hydration and sterochemical analysis

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Crystal structure of human angiogenin reveals the structural basis for its functional divergence from ribonuclease

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Specificity of pancreatic ribonuclease-A. An X-ray study of a protein-nucleotide complex

21 January 2018

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Effect of N-terminal and Met23 mutations on the structure and dynamics of onconase

21 January 2018

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Atomic resolution structures of ribonuclease A at six pH values

21 January 2018

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Conformational strictness required for maximum activity and stability of bovine pancreatic ribonuclease A as revealed by crystallographic study of three Phe120 mutants at 1.4 Å resolution

21 January 2018

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Mechanism of protein stabilization by disulfide bridges: calorimetric unfolding studies on disulfide-deficient mutants of the alpha-amylase inhibitor tendamistat

21 January 2018

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Comparison of backbone dynamics of reduced and oxidized Escherichia coli glutaredoxin-1 using 15N NMR relaxation measurements.

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1H and 15N resonance assignments and secondary structure of the human thioredoxin C62A, C69A, C73A mutant

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NMR structural analysis of an analog of an intermediate formed in the rate-determining step of one pathway in the oxidative folding of bovine pancreatic ribonuclease A: automated analysis of 1H, 13C, and 15N resonance assignments for wild-type and [

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Secretion efficiency in Saccharomyces cerevisiae of bovine pancreatic trypsin inhibitor mutants lacking disulfide bonds is correlated with thermodynamic stability

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Comparison of backbone and tryptophan side-chain dynamics of reduced and oxidized Escherichia coli thioredoxin using 15N NMR relaxation measurements.

21 January 2018

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Molecular evolution of the ribonuclease superfamily

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Structural and dynamic effects of alpha-helix deletion in Sso7d: implications for protein thermal stability

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The structures of RNase A complexed with 3'-CMP and d(CpA): active site conformation and conserved water molecules

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Binding of a substrate analog to a domain swapping protein: X-ray structure of the complex of bovine seminal ribonuclease with uridylyl(2′,5′)adenosine

21 January 2018

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Population shift vs induced fit: the case of bovine seminal ribonuclease swapping dimer

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21 January 2018

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Effective expression and purification of recombinant onconase, an antitumor protein

21 January 2018

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Crystalline ribonuclease A loses function below the dynamical transition at 220 K

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21 January 2018

Identifiers

DOI

10.1074/JBC.M501339200

1 reference

17 March 2018

1 reference

17 March 2018