(Q50676792)

17 March 2018

title

Prosurvival and proapoptotic intracellular signaling in rat spiral ganglion neurons in vivo after the loss of hair cells. (English)

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17 March 2018

author name string

Shaheen A Alam

1

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17 March 2018

Barbara K Robinson

2

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17 March 2018

Jie Huang

3

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17 March 2018

Steven H Green

4

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17 March 2018

language of work or name

English

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publication date

1 August 2007

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17 March 2018

The Journal of Comparative Neurology

published in

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17 March 2018

volume

503

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17 March 2018

issue

6

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17 March 2018

page(s)

832-852

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17 March 2018

Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential.

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Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression

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Survival of spiral ganglion cells in profound sensorineural hearing loss: implications for cochlear implantation.

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CREB-binding protein and p300 in transcriptional regulation

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Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis

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Pathological findings in the human auditory system following long-standing gentamicin ototoxicity

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7 January 2021

Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis.

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Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad.

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Degeneration of cochlear neurons after amikacin intoxication in the rat

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7 January 2021

Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation

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7 January 2021

Inhibition of the c-Jun N-terminal kinase signaling pathway influences neurite outgrowth of spiral ganglion neurons in vitro

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7 January 2021

An extranuclear locus of cAMP-dependent protein kinase action is necessary and sufficient for promotion of spiral ganglion neuronal survival by cAMP

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7 January 2021

Cellular survival: a play in three Akts

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7 January 2021

Signal transduction by the JNK group of MAP kinases

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7 January 2021

Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ral guanine nucleotide exchange factor-Ral pathway

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7 January 2021

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

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7 January 2021

Loss and survival of spiral ganglion neurons in the guinea pig after intracochlear perfusion with aminoglycosides

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7 January 2021

Response of spiral ganglion neurones to cochlear hair cell destruction in the guinea pig.

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7 January 2021

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7 January 2021

Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons.

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7 January 2021

Direct inhibition of c-Jun N-terminal kinase in sympathetic neurones prevents c-jun promoter activation and NGF withdrawal-induced death.

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7 January 2021

Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3.

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Severe sensory and sympathetic deficits in mice lacking neurotrophin-3.

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The mitochondrion: is it central to apoptosis?

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Making and breaking the innervation of the ear: neurotrophic support during ear development and its clinical implications

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7 January 2021

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

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7 January 2021

Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock

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7 January 2021

Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB.

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7 January 2021

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

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7 January 2021

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

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7 January 2021

c-Jun and the transcriptional control of neuronal apoptosis

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7 January 2021

Reciprocal signaling between spiral ganglion neurons and Schwann cells involves neuregulin and neurotrophins

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7 January 2021

Multiple distinct signal pathways, including an autocrine neurotrophic mechanism, contribute to the survival-promoting effect of depolarization on spiral ganglion neurons in vitro

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7 January 2021

Ca2+/calmodulin-dependent protein kinases II and IV both promote survival but differ in their effects on axon growth in spiral ganglion neurons.

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7 January 2021

Identification of JNK-dependent and -independent components of cerebellar granule neuron apoptosis

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7 January 2021

Trophic support of cultured spiral ganglion neurons by depolarization exceeds and is additive with that by neurotrophins or cAMP and requires elevation of [Ca2+]i within a set range.

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7 January 2021

The biochemistry of apoptosis

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7 January 2021

Apoptosis: corralling the corpses

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7 January 2021

Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury.

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7 January 2021

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

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7 January 2021

Auditory response to intracochlear electric stimuli following furosemide treatment.

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7 January 2021

Programmed cell death in animal development

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7 January 2021

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

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7 January 2021

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation

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7 January 2021

Glutamate modulates intracellular Ca2+ stores in brain stem auditory neurons

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7 January 2021

Spiral Ganglion Changes After Massive Aminoglycoside Treatment in the Guinea Pig

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7 January 2021

Sounding the alarm: protein kinase cascades activated by stress and inflammation

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7 January 2021

Glutamatergic inhibition of voltage-operated calcium channels in the avian cochlear nucleus

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7 January 2021

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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7 January 2021

In vitro and in vivo assessment of the ability of adeno-associated virus-brain-derived neurotrophic factor to enhance spiral ganglion cell survival following ototoxic insult

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7 January 2021

Cochlear pathology of long term neomycin induced deafness in cats

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7 January 2021

Chronic intracochlear electrical stimulation induces selective survival of spiral ganglion neurons in neonatally deafened cats

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7 January 2021

Chronic intracochlear electrical stimulation in neonatally deafened cats: effects of intensity and stimulating electrode location

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7 January 2021

Chronic electrical stimulation by a cochlear implant promotes survival of spiral ganglion neurons after neonatal deafness

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7 January 2021

Neurotrophins affect survival and neuritogenesis by adult injured auditory neurons in vitro

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7 January 2021

Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

1 reference

7 January 2021

Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover

1 reference

7 January 2021

The true face of JNK activation in apoptosis

1 reference

7 January 2021

An essential role for Rac/Cdc42 GTPases in cerebellar granule neuron survival

1 reference

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

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7 January 2021

Function and regulation of CREB family transcription factors in the nervous system

1 reference

7 January 2021

Effects of neurotrophins on early auditory neurones in cell culture.

1 reference

7 January 2021

Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway

1 reference

7 January 2021

Apoptosis. Key to the mitochondrial gate

1 reference

7 January 2021

Neurotrophins can enhance spiral ganglion cell survival after inner hair cell loss

1 reference

7 January 2021

Effects of chronic high-rate electrical stimulation on the cochlea and eighth nerve in the deafened guinea pig.

1 reference

7 January 2021

Docking interactions in the c-Jun N-terminal kinase pathway

1 reference

7 January 2021

Degeneration of cochlear neurons as seen in the spiral ganglion of man.

1 reference

7 January 2021

Morphologic study of effects of kanamycin on the developing cochlea of the rat.

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7 January 2021

JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

1 reference

7 January 2021

Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function

1 reference

7 January 2021

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

1 reference

7 January 2021

Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons

1 reference

7 January 2021

Qualitative and quantitative observations of spiral ganglion development in the rat.

1 reference

7 January 2021

Afferent regulation of neurons in the brain stem auditory system

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7 January 2021

Neuronal Loss in the Spiral Ganglion of Young Rats

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7 January 2021

Chronic depolarization enhances the trophic effects of brain-derived neurotrophic factor in rescuing auditory neurons following a sensorineural hearing loss.

1 reference

7 January 2021

Identification of a signaling pathway involved in calcium regulation of BDNF expression.

1 reference

7 January 2021

Neuronal sprouting and synapse formation in response to injury in the mouse organ of corti in culture

1 reference

7 January 2021

The block-surface technique for evaluation of cochlear pathology

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7 January 2021

A low-viscosity epoxy resin embedding medium for electron microscopy

1 reference

7 January 2021

NT-3 and/or BDNF therapy prevents loss of auditory neurons following loss of hair cells.

1 reference

7 January 2021

Brain-derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss

1 reference

7 January 2021

Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear.

1 reference

7 January 2021

Influence of supporting cells on neuronal degeneration after hair cell loss

1 reference

7 January 2021

Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity

1 reference

7 January 2021

Phosphorylation of c-Jun in avian and mammalian motoneurons in vivo during programmed cell death: an early reversible event in the apoptotic cascade.

1 reference

7 January 2021

Transcription factor phosphorylation by pp90(rsk2). Identification of Fos kinase and NGFI-B kinase I as pp90(rsk2).

1 reference

7 January 2021

Hearing loss and inner ear changes in a patient suffering from severe gentamicin ototoxicity.

1 reference

7 January 2021

Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism

1 reference

7 January 2021

Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons.

1 reference

7 January 2021

Multipolar spiral ganglion neurons following organ of Corti loss

1 reference

7 January 2021

Spiral ganglion neuron loss following organ of corti loss: A quantitative study

1 reference

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

7 January 2021

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

1 reference

7 January 2021

Cryoembedding and sectioning of cochleas for immunocytochemistry and in situ hybridization

1 reference

7 January 2021

Resprouting and survival of guinea pig cochlear neurons in response to the administration of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3.

1 reference

7 January 2021

N-methyl-D-aspartate blocks activation of JNK and mitochondrial apoptotic pathway induced by potassium deprivation in cerebellar granule cells.

1 reference

7 January 2021

The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis

1 reference

7 January 2021

Apoptosis in the nervous system

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7 January 2021

BDNF synthesis in spiral ganglion neurons is constitutive and CREB-dependent.

1 reference

7 January 2021

Patterns of degeneration in the human cochlear nerve

1 reference

7 January 2021

Eighth nerve activity regulates intracellular calcium concentration of avian cochlear nucleus neurons via a metabotropic glutamate receptor

1 reference

7 January 2021

Deafferentation increases the intracellular calcium of cochlear nucleus neurons in the embryonic chick

1 reference

7 January 2021

Activity-dependent regulation of [Ca2+]i in avian cochlear nucleus neurons: roles of protein kinases A and C and relation to cell death

1 reference

7 January 2021

AMPA receptor-mediated, calcium-dependent CREB phosphorylation in a subpopulation of auditory neurons surviving activity deprivation

1 reference

7 January 2021

Identifiers

DOI

10.1002/CNE.21430

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17 March 2018

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17 March 2018