(Q50692533)

17 March 2018

title

Discovery of a novel small-molecule targeting selective clearance of mutant huntingtin fragments. (English)

1 reference

17 March 2018

author name string

Myra Coufal

1

1 reference

17 March 2018

Michele M Maxwell

2

1 reference

17 March 2018

Deborah E Russel

3

1 reference

17 March 2018

Allison M Amore

4

1 reference

17 March 2018

Stephen M Altmann

5

1 reference

17 March 2018

Zane R Hollingsworth

6

1 reference

17 March 2018

Anne B Young

7

1 reference

17 March 2018

David E Housman

8

1 reference

17 March 2018

Aleksey G Kazantsev

9

1 reference

17 March 2018

publication date

22 March 2007

1 reference

17 March 2018

Journal of Biomolecular Screening

published in

1 reference

17 March 2018

volume

12

1 reference

17 March 2018

issue

3

1 reference

17 March 2018

page(s)

351-360

1 reference

17 March 2018

Normal huntingtin function: an alternative approach to Huntington's disease

cites work

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

Inactivation of the mouse Huntington's disease gene homolog Hdh

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

Wild type Huntingtin reduces the cellular toxicity of mutant Huntingtin in mammalian cell models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

Huntington's disease CAG trinucleotide repeats in pathologically confirmed post-mortem brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

Regional specificity of brain atrophy in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

Protein aggregation and neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

Biochemical, ultrastructural, and reversibility studies on huntingtin filaments isolated from mouse and human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

Full motor recovery despite striatal neuron loss and formation of irreversible amyloid-like inclusions in a conditional mouse model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

A cell-based screen for drugs to treat Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057107299428

21 January 2018

Identifiers

DOI

10.1177/1087057107299428

1 reference

17 March 2018

PubMed ID

17379859

1 reference

17 March 2018