(Q50781580)

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10 March 2020

title

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression (English)

1 reference

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10 March 2020

1 reference

5

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10 March 2020

Jo Vandesompele

21

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10 March 2020

Lukas C Heukamp

15

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10 March 2020

Rogier Versteeg

29

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10 March 2020

25

Frank Speleman

1 reference

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10 March 2020

28

Huib N Caron

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10 March 2020

19

Ludger Klein-Hitpass

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10 March 2020

author name string

Jan J Molenaar

1

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10 March 2020

Raquel Domingo-Fernández

2

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10 March 2020

Marli E Ebus

3

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10 March 2020

Sven Lindner

4

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10 March 2020

Ksenija Drabek

6

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10 March 2020

Pieter Mestdagh

7

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10 March 2020

Peter van Sluis

8

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10 March 2020

Linda J Valentijn

9

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10 March 2020

Johan van Nes

10

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10 March 2020

Marloes Broekmans

11

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10 March 2020

Franciska Haneveld

12

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10 March 2020

Richard Volckmann

13

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10 March 2020

Isabella Bray

14

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10 March 2020

Annika Sprüssel

16

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10 March 2020

Theresa Thor

17

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10 March 2020

Kristina Kieckbusch

18

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10 March 2020

Matthias Fischer

20

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10 March 2020

Alexander Schramm

22

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10 March 2020

Max M van Noesel

23

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10 March 2020

Luigi Varesio

24

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10 March 2020

Angelika Eggert

26

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10 March 2020

Raymond L Stallings

27

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10 March 2020

Johannes H Schulte

30

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10 March 2020

language of work or name

English

0 references

publication date

7 October 2012

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10 March 2020

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10 March 2020

volume

44

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10 March 2020

page(s)

1199-1206

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10 March 2020

issue

11

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https://scigraph.springernature.com/pub.10.1038/ng.2436

10 March 2020

exact match

0 references

cites work

The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA

1 reference

Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency

21 January 2018

1 reference

LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro

21 January 2018

1 reference

The Lin28/let-7 axis regulates glucose metabolism

21 January 2018

1 reference

Induced pluripotent stem cell lines derived from human somatic cells

21 January 2018

1 reference

Lin28 promotes transformation and is associated with advanced human malignancies

21 January 2018

1 reference

Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma

21 January 2018

1 reference

Lin-28B expression promotes transformation and invasion in human hepatocellular carcinoma

21 January 2018

1 reference

LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer

21 January 2018

1 reference

LIN28B promotes colon cancer progression and metastasis

21 January 2018

1 reference

Genetic variation in LIN28B is associated with the timing of puberty

21 January 2018

1 reference

Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche

21 January 2018

1 reference

Selective blockade of microRNA processing by Lin28

21 January 2018

1 reference

MicroRNA maturation: stepwise processing and subcellular localization

21 January 2018

1 reference

The nuclear RNase III Drosha initiates microRNA processing

21 January 2018

1 reference

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

21 January 2018

1 reference

Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28.

21 January 2018

1 reference

Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA

21 January 2018

1 reference

Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.

21 January 2018

1 reference

The let-7 family of microRNAs

21 January 2018

1 reference

The tumor suppressor microRNA let-7 represses the HMGA2 oncogene

21 January 2018

1 reference

Impaired microRNA processing enhances cellular transformation and tumorigenesis

21 January 2018

1 reference

The let-7 microRNA represses cell proliferation pathways in human cells

21 January 2018

1 reference

The role of let-7 in cell differentiation and cancer

21 January 2018

1 reference

Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival

21 January 2018

1 reference

Let-7 expression defines two differentiation stages of cancer

21 January 2018

1 reference

Progress in treatment and risk stratification of neuroblastoma: impact on future clinical and basic research

21 January 2018

1 reference

21 January 2018

1 reference

Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

21 January 2018

1 reference

Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survival

21 January 2018

1 reference

miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples

21 January 2018

1 reference

A genome-wide search for promoters that respond to increased MYCN reveals both new oncogenic and tumor suppressor microRNAs associated with aggressive neuroblastoma

21 January 2018

1 reference

MYCN regulates oncogenic MicroRNAs in neuroblastoma

21 January 2018

1 reference

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

21 January 2018

1 reference

MYCN-regulated microRNAs repress estrogen receptor-alpha (ESR1) expression and neuronal differentiation in human neuroblastoma

21 January 2018

1 reference

MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma

21 January 2018

1 reference

MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets

21 January 2018

1 reference

A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene

21 January 2018

1 reference

MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells

21 January 2018

1 reference

Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma

21 January 2018

1 reference

Copy number defects of G1-cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis.

21 January 2018

1 reference

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

21 January 2018

1 reference

Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp 130 signaling.

21 January 2018

1 reference

Targeted expression of MYCN causes neuroblastoma in transgenic mice

21 January 2018

1 reference

Targeting MYC dependence in cancer by inhibiting BET bromodomains

21 January 2018

1 reference

MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2.

21 January 2018

1 reference

MicroRNA-125b/Lin28 pathway contributes to the mesendodermal fate decision of embryonic stem cells

21 January 2018

1 reference

A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

21 January 2018

1 reference

Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers

21 January 2018

1 reference

N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b

21 January 2018

1 reference

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

21 January 2018

1 reference

Systematic gene regulation involving miRNAs during neuronal differentiation of mouse P19 embryonic carcinoma cell

21 January 2018

1 reference

A developmental timing switch promotes axon outgrowth independent of known guidance receptors

21 January 2018

1 reference

Identification of a novel recurrent 1q42.2-1qter deletion in high risk MYCN single copy 11q deleted neuroblastomas

21 January 2018

1 reference

Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma

21 January 2018

1 reference

Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma.

21 January 2018

1 reference

Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells

21 January 2018

1 reference

Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

21 January 2018

1 reference

High-throughput stem-loop RT-qPCR miRNA expression profiling using minute amounts of input RNA.

21 January 2018

1 reference

A novel and universal method for microRNA RT-qPCR data normalization

21 January 2018

1 reference

Targeted expression of mutated ALK induces neuroblastoma in transgenic mice.

21 January 2018

1 reference

Cytohesins are cytoplasmic ErbB receptor activators

21 January 2018

1 reference

Cyclin D1 is a direct transcriptional target of GATA3 in neuroblastoma tumor cells

21 January 2018

1 reference

Allelic loss of chromosome 1p36 in neuroblastoma is of preferential maternal origin and correlates with N-myc amplification

21 January 2018

1 reference

12 December 2020

A role for Lin28 in primordial germ-cell development and germ-cell malignancy

1 reference

12 December 2020

Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma

1 reference

12 December 2020

Inhibition of a new differentiation pathway in neuroblastoma by copy number defects of N-myc, Cdc42, and nm23 genes.

1 reference

12 December 2020

MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells

1 reference

12 December 2020

PIKE mediates EGFR proliferative signaling in squamous cell carcinoma cells

1 reference

7 January 2021