(Q50825765)

English

Models of hepatic elimination: Comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity, and systemic recycling on hepatic elimination

scientific article published in February 1988

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3373419%20AND%20SRC:MED&resulttype=core&format=json

23 September 2019

Models of hepatic elimination: comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity, and systemic recycling on hepatic elimination (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3373419%20AND%20SRC:MED&resulttype=core&format=json

23 September 2019

0 references

stochastic modelling

0 references

modelling biological systems

0 references

Michael S. Roberts

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3373419%20AND%20SRC:MED&resulttype=core&format=json

23 September 2019

author name string

J D Donaldson

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3373419%20AND%20SRC:MED&resulttype=core&format=json

23 September 2019

M Rowland

3

1 reference

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23 September 2019

publication date

1 February 1988

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3373419%20AND%20SRC:MED&resulttype=core&format=json

23 September 2019

Journal of Pharmacokinetics and Pharmacodynamics

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3373419%20AND%20SRC:MED&resulttype=core&format=json

23 September 2019

16

1 reference

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23 September 2019

41-83

1 reference

Europe PubMed Central

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23 September 2019

1

1 reference

Europe PubMed Central

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23 September 2019

https://scigraph.springernature.com/pub.10.1007/bf01061862

0 references

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

1 reference

https://api.crossref.org/works/10.1007%2FBF01061862

21 January 2018

Hepatic elimination of flowing substrates: the distributed model

1 reference

https://api.crossref.org/works/10.1007%2FBF01061862

21 January 2018

On the relation between extended forms of the sinusoidal perfusion and of the convection-dispersion models of hepatic elimination

1 reference

https://api.crossref.org/works/10.1007%2FBF01061862

21 January 2018

Moments of physiological transit time distributions and the time course of drug disposition in the body.

1 reference

https://api.crossref.org/works/10.1007%2FBF01061862

21 January 2018

A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.

1 reference

https://api.crossref.org/works/10.1007%2FBF01061862

21 January 2018

Vasomotor control of capillary transit time heterogeneity in the canine coronary circulation

1 reference

https://api.crossref.org/works/10.1007%2FBF01061862

21 January 2018

A dispersion model of hepatic elimination: 3. Application to metabolite formation and elimination kinetics.

1 reference

https://api.crossref.org/works/10.1007%2FBF01061862

21 January 2018

Use of gamma distributed residence times in pharmacokinetics.

1 reference

https://api.crossref.org/works/10.1007%2FBF01061862

21 January 2018

Clearance concepts in pharmacokinetics

1 reference

https://api.crossref.org/works/10.1007%2FBF01061862

21 January 2018

Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

1 reference

https://api.crossref.org/works/10.1007%2FBF01061862

21 January 2018

An understanding of the role of enzyme localization of the liver on metabolite kinetics: a computer simulation.

1 reference

https://api.crossref.org/works/10.1007%2FBF01061862

21 January 2018

Flow dependence of first-order uptake of substances by heterogeneous perfused organs

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Models of hepatic drug clearance: discrimination between the ‘well stirred’ and ‘parallel-tube’ models

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Convection-dispersion modeling of hepatic elimination

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Curve fitting and modeling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tracer dilution curves in cardiology and random walk and lognormal distributions

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Albumin binding and hepatic uptake: the importance of model selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THEORY OF THE USE OF ARTERIOVENOUS CONCENTRATION DIFFERENCES FOR MEASURING METABOLISM IN STEADY AND NON-STEADY STATES.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional implications of liver cell heterogeneity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of sinusoidal perfusion on galactose elimination kinetics in perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dispersion model of hepatic elimination: 2. Steady-state considerations-influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the uptake of materials by the intact liver. The transport and net removal of galactose

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic drug clearance model: comparison among the distributed, parallel-tube and well-stirred models

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic interpretation of hepatic multiple-indicator dilution studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic transport kinetics: effect of anatomic and metabolic heterogeneity on estimates of the average transfer coefficients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flow dependence of propranolol elimination in perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of ligandin in transfer of bilirubin from plasma into liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The terminal hepatic microcirculation in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hepatic sinusoid is not well-stirred: estimation of the degree of axial mixing by analysis of lobular concentration gradients formed during uptake of thyroxine by the perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissociation from albumin: a potentially rate-limiting step in the clearance of substances by the liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic transport kinetics and plasma disappearance curves: distributed modeling versus conventional approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Saturation kinetics in hepatic drug removal: a statistical approach to functional heterogeneity

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discrimination between the venous equilibrium and sinusoidal models of hepatic drug elimination in the isolated perfused rat liver by perturbation of propranolol protein binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/3373419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF01061862

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3373419%20AND%20SRC:MED&resulttype=core&format=json

23 September 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3373419%20AND%20SRC:MED&resulttype=core&format=json

23 September 2019

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