(Q51005199)

26 March 2018

title

Metabolic regulation of osteoclast differentiation and function. (English)

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author name string

Yoriko Indo

1

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Sunao Takeshita

2

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Kiyo-Aki Ishii

3

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Takayuki Hoshii

4

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Hiroyuki Aburatani

5

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Atsushi Hirao

6

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Kyoji Ikeda

7

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publication date

1 November 2013

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Journal of Bone and Mineral Research

published in

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volume

28

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issue

11

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page(s)

2392-2399

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Reaching a genetic and molecular understanding of skeletal development

cites work

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Genetic regulation of osteoclast development and function

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Osteoclast differentiation and activation

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Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation

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SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts

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mTORC1 is essential for leukemia propagation but not stem cell self-renewal

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In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

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Identification and functional expression of the mitochondrial pyruvate carrier

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Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia

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Bidirectional transport of amino acids regulates mTOR and autophagy

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

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21 January 2018

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21 January 2018

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Revving the engine: signal transduction fuels T cell activation.

21 January 2018

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The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.

21 January 2018

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Hypoxia is a major stimulator of osteoclast formation and bone resorption.

21 January 2018

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Acute hypoxia and osteoclast activity: a balance between enhanced resorption and increased apoptosis

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Osteoclast precursors display dynamic metabolic shifts toward accelerated glucose metabolism at an early stage of RANKL-stimulated osteoclast differentiation

21 January 2018

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c-myc is required for osteoclast differentiation

21 January 2018

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Transcription from the tartrate-resistant acid phosphatase promoter is negatively regulated by the Myc oncoprotein

21 January 2018

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Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors

21 January 2018

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M-CSF, TNFα and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase

21 January 2018

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Rapamycin and the transcription factor C/EBPbeta as a switch in osteoclast differentiation: implications for lytic bone diseases

21 January 2018

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Everolimus suppresses cancellous bone loss, bone resorption, and cathepsin K expression by osteoclasts

21 January 2018

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Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JBMR.1976

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