(Q51012800)

English

Loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility.

scientific article published in April 2011

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scholarly article

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28 January 2020

Loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility (English)

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28 January 2020

Solute carrier family 7 (cationic amino acid transporter, y+ system), member 11

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GOA release 2020-03-11

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based on heuristic

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Dimitri De Bundel

1

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28 January 2020

author name string

Anneleen Schallier

2

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28 January 2020

Ellen Loyens

3

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28 January 2020

Ruani Fernando

4

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28 January 2020

Hirohisa Miyashita

5

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28 January 2020

Joeri Van Liefferinge

6

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28 January 2020

Katia Vermoesen

7

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28 January 2020

Shiro Bannai

8

1 reference

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28 January 2020

Hideyo Sato

9

1 reference

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28 January 2020

Yvette Michotte

10

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28 January 2020

Ilse Smolders

11

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28 January 2020

Ann Massie

12

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28 January 2020

language of work or name

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publication date

1 April 2011

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28 January 2020

number of pages

12

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Journal of Neuroscience

1 reference

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28 January 2020

31

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28 January 2020

5792-5803

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28 January 2020

15

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28 January 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6622811/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral and biochemical effects of glutathione depletion in the rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and characterization of uptake systems for cystine and cysteine in cultured astrocytes and neurons: evidence for methylmercury-targeted disruption of astrocyte transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spatial memory dissociations in mice lacking GluR1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The origin and neuronal function of in vivo nonsynaptic glutamate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in dialysate concentrations of glutamate and GABA in the brain: an index of volume transmission mediated actions?

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A within-subjects, within-task demonstration of intact spatial reference memory and impaired spatial working memory in glutamate receptor-A-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Malignant gliomas: perverting glutamate and ion homeostasis for selective advantage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the effect of glutamate receptor modulators in the 6 Hz and maximal electroshock seizure models

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation of substrate and non-substrate inhibitors of transport system xc(-): an obligate exchanger of L-glutamate and L-cystine

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Status epilepticus after a massive intravenous N-acetylcysteine overdose leading to intracranial hypertension and death

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of extracellular glutamate in the prefrontal cortex: focus on the cystine glutamate exchanger and group I metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of amino acids associated with cerebral ischaemia in rat brain microdialysates using narrowbore liquid chromatography and fluorescence detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic deletion of the norepinephrine transporter decreases vulnerability to seizures

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cystine uptake disrupts the growth of primary brain tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An astrocytic basis of epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox imbalance in cystine/glutamate transporter-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

System Xc- and apolipoprotein E expressed by microglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T-maze alternation in the rodent.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular regulation of antioxidant ability in the hippocampus of EL mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time-dependent changes in striatal xCT protein expression in hemi-Parkinson rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Levetiracetam enhances endogenous antioxidant in the hippocampus of rats: in vivo evaluation by brain microdialysis combined with ESR spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-N-methylamino-l-alanine induces oxidative stress and glutamate release through action on system Xc(-).

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc- as a neuroprotective drug target

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time-dependent changes in GLT-1 functioning in striatum of hemi-Parkinson rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Region- and age-specific changes in glutamate transport in the AβPP23 mouse model for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exchange of cystine and glutamate across plasma membrane of human fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cognitive functions of cortical ACh: lessons from studies on trans-synaptic modulation of activated efflux

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cystine uptake and glutathione level in fetal brain cells in primary culture and in suspension

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of N6-cyclopentyl adenosine and 8-cyclopentyl-1,3-dipropylxanthine on N-methyl-D-aspartate induced seizures in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Status epilepticus following intravenous N-acetylcysteine therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Utilization of cysteine and cysteine precursors for the synthesis of glutathione in astroglial cultures: preference for cystine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate transporter GLT-1 is transiently localized on growing axons of the mouse spinal cord before establishing astrocytic expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5465-10.2011

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490221%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490221%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490221%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

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