(Q51034608)

27 March 2018

title

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment (English)

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

30 July 2024

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mild cognitive impairment

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9

Daniel Guay

1 reference

27 March 2018

Robert N Young

22

object named as

Robert N. Young

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20933411

30 July 2024

author name string

Michel Gallant

1

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27 March 2018

Renee Aspiotis

2

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27 March 2018

Stephen Day

3

1 reference

27 March 2018

Rebecca Dias

4

1 reference

27 March 2018

Daniel Dubé

5

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27 March 2018

Laurence Dubé

6

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27 March 2018

Mario Girard

8

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27 March 2018

Pierre Hamel

10

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27 March 2018

Zheng Huang

11

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27 March 2018

Patrick Lacombe

12

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27 March 2018

Sebastien Laliberté

13

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27 March 2018

Jean-François Lévesque

14

1 reference

27 March 2018

Susana Liu

15

1 reference

27 March 2018

Dwight Macdonald

16

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27 March 2018

Joseph Mancini

17

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27 March 2018

Angela Styhler

19

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27 March 2018

Karen Townson

20

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27 March 2018

Kerry Waters

21

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27 March 2018

Yves Girard

23

1 reference

27 March 2018

Richard W. Friesen

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20933411

30 July 2024

Donald W. Nicholson

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20933411

30 July 2024

language of work or name

English

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publication date

21 September 2010

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27 March 2018

full work available at URL

https://api.elsevier.com/content/article/PII:S0960894X1001396X?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

https://api.elsevier.com/content/article/PII:S0960894X1001396X?httpAccept=text/plain

30 July 2024

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

Bioorganic & Medicinal Chemistry Letters

30 July 2024

published in

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27 March 2018

volume

20

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27 March 2018

issue

22

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27 March 2018

page(s)

6387-6393

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27 March 2018

Bis(oxazolines) as chiral ligands in metal-catalyzed asymmetric reactions. Catalytic, asymmetric cyclopropanation of olefins

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Molecular mechanism of neuronal plasticity: induction and maintenance of long-term potentiation in the hippocampus

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CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models.

30 July 2024

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https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

PDE4 inhibitors: a review of current developments (2005 - 2009).

30 July 2024

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Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

30 July 2024

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https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

Phosphodiesterase inhibitors as potential cognition enhancing agents

30 July 2024

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https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

Selective phosphodiesterase (PDE)-4 inhibitors: a novel approach to treating memory deficit?

30 July 2024

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https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

Phosphodiesterase-4 as a potential drug target

30 July 2024

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Time-dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors

30 July 2024

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30 July 2024

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Sub-chronic rolipram treatment leads to a persistent improvement in long-term object memory in rats

30 July 2024

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Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats.

30 July 2024

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The role of phosphodiesterase enzymes in allergy and asthma

30 July 2024

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Hunting the emesis and efficacy targets of PDE4 inhibitors: identification of the photoaffinity probe 8-(3-azidophenyl)-6- [(4-iodo-1H-1-imidazolyl)methyl]quinoline (APIIMQ).

30 July 2024

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Journal of Pharmacology and Experimental Therapeutics

30 July 2024

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Neuroanatomical and pharmacological assessment of Fos expression induced in the rat brain by the phosphodiesterase-4 inhibitor 6-(4-pyridylmethyl)-8-(3-nitrophenyl) quinoline

30 July 2024

18

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

Neural substrates for conditioned taste aversion in the rat.

30 July 2024

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Neural mechanisms of taste aversion learning

30 July 2024

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https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition

30 July 2024

21

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The use of the Morris Water Maze in the study of memory and learning

30 July 2024

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Preferential inhibition of T helper 1, but not T helper 2, cytokines in vitro by L-826,141 [4-[2-(3,4-Bisdifluromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]3-methylpyridine-1-oxide], a potent and selective phospho

30 July 2024

23

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

Phosphodiesterase 4 inhibitors for the treatment of asthma and COPD

30 July 2024

24

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor-alpha and leukotriene B4 in a novel human whole blood assay

30 July 2024

25

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

Conformational difference between PDE4 apoenzyme and holoenzyme

30 July 2024

26

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https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors.

30 July 2024

27

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain

30 July 2024

28

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition

30 July 2024

30

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor.

30 July 2024

31

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

Optimization and structure-activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: identification of MK-0873, a potent and effective PDE4 inhibitor

30 July 2024

33

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

Design, synthesis, and biological evaluation of 8-biarylquinolines: a novel class of PDE4 inhibitors

30 July 2024

34

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https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

Free drug concentration monitoring in clinical practice. Rationale and current status

30 July 2024

35

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https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

Preparation of some substituted beta-phenylisovaleric acids

30 July 2024

39

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https://api.crossref.org/works/10.1016/J.BMCL.2010.09.087

30 July 2024

Identifiers

1 reference

27 March 2018

1 reference

27 March 2018