(Q51034812)

27 March 2018

title

LRIG1 modulates aggressiveness of head and neck cancers by regulating EGFR-MAPK-SPHK1 signaling and extracellular matrix remodeling. (English)

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27 March 2018

author name string

J J-C Sheu

1

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27 March 2018

C-C Lee

2

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27 March 2018

C-H Hua

3

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27 March 2018

C-I Li

4

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27 March 2018

M-T Lai

5

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27 March 2018

S-C Lee

6

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27 March 2018

J Cheng

7

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27 March 2018

C-M Chen

8

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27 March 2018

C Chan

9

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27 March 2018

S C-C Chao

10

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27 March 2018

J-Y Chen

11

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27 March 2018

J-Y Chang

12

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27 March 2018

C-H Lee

13

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27 March 2018

language of work or name

English

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publication date

29 April 2013

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27 March 2018

published in

Oncogene

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27 March 2018

volume

33

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27 March 2018

issue

11

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27 March 2018

page(s)

1375-1384

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27 March 2018

Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment

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Is LRIG1 a tumour suppressor gene at chromosome 3p14.3?

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LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII.

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Paracrine regulation of growth factor signaling by shed leucine-rich repeats and immunoglobulin-like domains 1.

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A soluble ectodomain of LRIG1 inhibits cancer cell growth by attenuating basal and ligand-dependent EGFR activity

21 January 2018

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The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases

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Upregulation of LRIG1 suppresses malignant glioma cell growth by attenuating EGFR activity

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21 January 2018

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EGFR kinase promotes acquisition of stem cell-like properties: a potential therapeutic target in head and neck squamous cell carcinoma stem cells

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Targeting SphK1 as a new strategy against cancer

21 January 2018

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Prognostic significance of tumor angiogenesis, Ki 67, p53 oncoprotein, epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal carcinoma--a prospective study.

21 January 2018

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Analysis of EGFR signaling pathway in nasopharyngeal carcinoma cells by quantitative phosphoproteomics

21 January 2018

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Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix

21 January 2018

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21 January 2018

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Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

21 January 2018

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Lrig1: a new master regulator of epithelial stem cells.

21 January 2018

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Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition.

21 January 2018

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Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells

21 January 2018

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21 January 2018

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21 January 2018

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LRIG inhibitors of growth factor signalling - double-edged swords in human cancer?

21 January 2018

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Cell Adhesion Induces the Plasminogen Activator Inhibitor-1 Gene Expression through Phosphatidylinositol 3-Kinase/Akt Activation in Anchorage Dependent Cells

21 January 2018

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Karyotypic evolution and tumor progression in head and neck squamous cell carcinomas

21 January 2018

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LRIG1 and squamous epithelial uterine cervical cancer: correlation to prognosis, other tumor markers, sex steroid hormones, and smoking

31 March 2020

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Extracellular ATP activates nuclear translocation of ERK1/2 leading to the induction of matrix metalloproteinases expression in human endometrial stromal cells

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2013.98

1 reference

27 March 2018

1 reference

27 March 2018