(Q51058644)

27 March 2018

title

Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection. (English)

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27 March 2018

3

Christopher Burlak

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27 March 2018

A Joseph Tector

12

object named as

A Joseph Tector

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27 March 2018

author name string

Ping Li

1

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27 March 2018

Jose L Estrada

2

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27 March 2018

Jessica Montgomery

4

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James R Butler

5

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Rafael M Santos

6

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Zheng-Yu Wang

7

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Leela L Paris

8

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Ross L Blankenship

9

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Susan M Downey

10

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Matthew Tector

11

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27 March 2018

publication date

2 September 2014

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27 March 2018

published in

Xenotransplantation

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27 March 2018

volume

22

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issue

1

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page(s)

20-31

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27 March 2018

Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys

cites work

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Rejection of cardiac xenografts transplanted from alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs to baboons

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No shortcuts to pig embryonic stem cells

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Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs

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Production of alpha 1,3-galactosyltransferase-knockout cloned pigs expressing human alpha 1,2-fucosylosyltransferase.

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21 January 2018

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Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

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Biallelic knockout of the α-1,3 galactosyltransferase gene in porcine liver-derived cells using zinc finger nucleases.

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Double knockout pigs deficient in N-glycolylneuraminic acid and galactose α-1,3-galactose reduce the humoral barrier to xenotransplantation

21 January 2018

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Targeting DNA With Fingers and TALENs

21 January 2018

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RNA-guided human genome engineering via Cas9

21 January 2018

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Multiplex genome engineering using CRISPR/Cas systems

21 January 2018

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One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

21 January 2018

1 reference

Efficient selection of Gal-knockout pig cells for somatic cell nuclear transfer

21 January 2018

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Production of alpha 1,3-galactosyltransferase gene-deficient pigs by somatic cell nuclear transfer: a novel selection method for gal alpha 1,3-Gal antigen-deficient cells

21 January 2018

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Swine generated by somatic cell nuclear transfer have increased incidence of intrauterine growth restriction (IUGR).

21 January 2018

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Efficient TALEN-mediated gene knockout in livestock

21 January 2018

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Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid

21 January 2018

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CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

21 January 2018

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High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

21 January 2018

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DNA targeting specificity of RNA-guided Cas9 nucleases

21 January 2018

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Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases.

21 January 2018

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CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

21 January 2018

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Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

21 January 2018

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Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

21 January 2018

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Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

21 January 2018

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Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

21 January 2018

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Alpha1,3-galactosyltransferase gene-knockout pigs for xenotransplantation: where do we go from here?

21 January 2018

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21 January 2018

Gal knockout and beyond

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Efficient generation of large-scale genome-modified mice using gRNA and CAS9 endonuclease

21 January 2018

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A rapid and general assay for monitoring endogenous gene modification

21 January 2018

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Carbohydrate residues downstream of the terminal Galalpha(1,3)Gal epitope modulate the specificity of xenoreactive antibodies.

21 January 2018

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The molecular basis for galalpha(1,3)gal expression in animals with a deletion of the alpha1,3galactosyltransferase gene.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/XEN.12131

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27 March 2018

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27 March 2018