(Q51139133)

English

Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia.

scientific article published on 13 February 2017

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scholarly article

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Europe PubMed Central

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2 April 2020

Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia (English)

1 reference

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2 April 2020

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Andrew Intlekofer

6

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2 April 2020

Christopher E. Mason

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Christopher E Mason

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2 April 2020

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Cem Meydan

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2 April 2020

Craig B. Thompson

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Craig B Thompson

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2 April 2020

author name string

Alan H Shih

1

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2 April 2020

Kaitlyn Shank

3

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2 April 2020

Francine E Garrett-Bakelman

4

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2 April 2020

Patrick S Ward

5

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2 April 2020

Abbas Nazir

7

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2 April 2020

Eytan M Stein

8

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2 April 2020

Kristina Knapp

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2 April 2020

Jacob Glass

10

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2 April 2020

Jeremy Travins

11

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2 April 2020

Kim Straley

12

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2 April 2020

Camelia Gliser

13

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2 April 2020

Katharine Yen

15

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2 April 2020

Ari Melnick

17

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2 April 2020

Ross L Levine

18

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2 April 2020

publication date

13 February 2017

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2 April 2020

Cancer Discovery

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2 April 2020

7

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2 April 2020

5

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2 April 2020

494-505

1 reference

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2 April 2020

TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

1 reference

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10 June 2018

IDH mutations in cancer and progress toward development of targeted therapeutics

1 reference

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10 June 2018

IDH2 inhibition in AML: Finally progress?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia

1 reference

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10 June 2018

WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia

1 reference

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10 June 2018

Age-related clonal hematopoiesis associated with adverse outcomes

1 reference

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10 June 2018

IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

Age-related mutations associated with clonal hematopoietic expansion and malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

An optimized algorithm for detecting and annotating regional differential methylation

1 reference

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10 June 2018

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

1 reference

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10 June 2018

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles

1 reference

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10 June 2018

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.

1 reference

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10 June 2018

The role of mutations in epigenetic regulators in myeloid malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

RNA-dependent inhibition of ribonucleotide reductase is a major pathway for 5-azacytidine activity in acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

1 reference

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10 June 2018

Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knockin mice

1 reference

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10 June 2018

TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

Inhibition of 2-oxoglutarate dependent oxygenases

1 reference

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10 June 2018

TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

1 reference

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10 June 2018

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413413

10 June 2018

DNMT3A Mutations in Acute Myeloid Leukemia

1 reference

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10 June 2018

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

1 reference

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10 June 2018

Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial

1 reference

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10 June 2018

A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines

1 reference

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10 June 2018

DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.

1 reference

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10 June 2018

Recurring mutations found by sequencing an acute myeloid leukemia genome

1 reference

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10 June 2018

Mutation in TET2 in myeloid cancers

1 reference

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10 June 2018

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

1 reference

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10 June 2018

Dynamics of chronic myeloid leukaemia.

1 reference

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10 June 2018

Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging.

1 reference

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14 August 2018

Adverse impact of IDH1 and IDH2 mutations in primary AML: Experience of the Spanish CETLAM group

1 reference

https://pubmed.ncbi.nlm.nih.gov/28193779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias

1 reference

https://pubmed.ncbi.nlm.nih.gov/28193779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/28193779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/2159-8290.CD-16-1049

1 reference

Europe PubMed Central

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2 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28193779%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28193779%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

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