Wikidata

(Q511968)

English

Cyclin dependent kinase 2

mammalian protein found in Homo sapiens

  • cell division protein kinase 2
  • cdc2-related protein kinase
  • p33 protein kinase
  • cyclin-dependent kinase 2
  • CDK2
In more languages

Statements

molecular function
protein binding
determination method
IPI
61 references
retrieved
1 January 2018
stated in
Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2
GOA
curator
UniProt
UniProt protein ID
P24941
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins
GOA
curator
UniProt
UniProt protein ID
P24941
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Identification and characterization of CAC1 as a novel CDK2-associated cullin
GOA
curator
UniProt
UniProt protein ID
P24941
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity
GOA
curator
UniProt
UniProt protein ID
P24941
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Overexpression of DOC-1R inhibits cell cycle G1/S transition by repressing CDK2 expression and activation
GOA
curator
UniProt
UniProt protein ID
P24941
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins
GOA
curator
UniProt
UniProt protein ID
P24941
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17
GOA
curator
UniProt
UniProt protein ID
P24941
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Human Spy1 promotes survival of mammalian cells following DNA damage
GOA
curator
UniProt
UniProt protein ID
P24941
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry
GOA
curator
UniProt
UniProt protein ID
P24941
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2
GOA
curator
UniProt
UniProt protein ID
P24941
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Role of T198 modification in the regulation of p27(Kip1) protein stability and function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Cyclin-binding motifs are essential for the function of p21CIP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Self-assembling protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
NIRF induces G1 arrest and associates with Cdk2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Foxp3 protein stability is regulated by cyclin-dependent kinase 2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
C-terminal phosphorylation controls the stability and function of p27kip1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Structural basis of cyclin-dependent kinase activation by phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
The crystal structure of human CDK7 and its protein recognition properties
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
The protein interaction landscape of the human CMGC kinase group
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Expanding the substantial interactome of NEMO using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Specificity of cyclin E-Cdk2, TFIIB, and E1A interactions with a common domain of the p300 coactivator
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Honokiol causes the p21WAF1-mediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
HTLV-I p30 inhibits multiple S phase entry checkpoints, decreases cyclin E-CDK2 interactions and delays cell cycle progression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γ
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
cyclin binding
determination method
IBA
IDA
IEA
IPI
6 references
retrieved
1 January 2018
stated in
Cyclin A is required at two points in the human cell cycle
GOA
curator
UniProt
UniProt protein ID
P24941
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IPI
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IEA
retrieved
1 January 2018
stated in
Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase
GOA
curator
UniProt
UniProt protein ID
P24941
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IDA
retrieved
1 January 2018
stated in
Overexpression of DOC-1R inhibits cell cycle G1/S transition by repressing CDK2 expression and activation
GOA
curator
UniProt
UniProt protein ID
P24941
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IBA
cell component
cyclin A2-CDK2 complex
determination method
IDA
IEA
6 references
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IEA
retrieved
1 January 2018
stated in
Cyclin A is required at two points in the human cell cycle
GOA
curator
UniProt
UniProt protein ID
P24941
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IDA
retrieved
1 January 2018
stated in
p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IDA
retrieved
1 January 2018
stated in
Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IDA
retrieved
1 January 2018
stated in
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IDA
retrieved
1 January 2018
stated in
Intrinsic structural disorder and sequence features of the cell cycle inhibitor p57Kip2
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941
determination method
IDA
biological process
physically interacts with

Identifiers

MeSH descriptor ID
D051357
subject named as
Cyclin-Dependent Kinase 2
0 references
OMIM ID
116953
0 references
PDB structure ID
 
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