(Q51498602)

English

Sulforaphane Regulates NFE2L2/Nrf2-Dependent Xenobiotic Metabolism Phase II and Phase III Enzymes Differently in Human Colorectal Cancer and Untransformed Epithelial Colon Cells.

scientific article published on 16 September 2016

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scholarly article

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23 March 2020

Sulforaphane Regulates NFE2L2/Nrf2-Dependent Xenobiotic Metabolism Phase II and Phase III Enzymes Differently in Human Colorectal Cancer and Untransformed Epithelial Colon Cells (English)

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23 March 2020

colorectal cancer

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based on heuristic

inferred from title

Katarzyna Wiktorska

2

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23 March 2020

Małgorzata Milczarek

4

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23 March 2020

Zdzisław Chilmonczyk

6

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23 March 2020

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Katarzyna Lubelska

1

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23 March 2020

Lidia Mielczarek

3

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23 March 2020

Ilona Zbroińska-Bregisz

5

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23 March 2020

publication date

16 September 2016

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23 March 2020

Nutrition and Cancer

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23 March 2020

68

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23 March 2020

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23 March 2020

1338-1348

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23 March 2020

Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis

1 reference

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The chemical diversity and distribution of glucosinolates and isothiocyanates among plants

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Protective effect of sulforaphane against oxidative stress: recent advances

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Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters

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Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

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21 January 2018

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

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Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes

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Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling Pathway

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Effect of melatonin on the expression of Nrf2 and NF-kappaB during cyclophosphamide-induced urinary bladder injury in rat.

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Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

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Dual roles of Nrf2 in cancer

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The emerging role of the Nrf2-Keap1 signaling pathway in cancer

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Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

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Nrf2 pathway regulates multidrug-resistance-associated protein 1 in small cell lung cancer

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Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1).

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Sulforaphane and erucin increase MRP1 and MRP2 in human carcinoma cell lines.

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Paradoxical roles for antioxidants in tumor prevention and eradication

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Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine

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21 January 2018

Anticancer activity of a broccoli derivative, sulforaphane, in barrett adenocarcinoma: potential use in chemoprevention and as adjuvant in chemotherapy

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21 January 2018

Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: A screening assay for anticarcinogenic enzyme inducers

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Novel fluorescence assay using calcein-AM for the determination of human erythrocyte viability and aging

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Activity and expression of the multidrug resistance proteins P-glycoprotein, MRP1, MRP2, MRP3 and MRP5 in de novo and relapsed acute myeloid leukemia

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Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems.

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21 January 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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21 January 2018

Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene.

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21 January 2018

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Transactivation of Genes Encoding for Phase II Enzymes and Phase III Transporters by Phytochemical Antioxidants

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Nuclear receptor-mediated transcriptional regulation in Phase I, II, and III xenobiotic metabolizing systems

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Synergistic inhibitory effect of sulforaphane and 5-fluorouracil in high and low metastasis cell lines of salivary gland adenoid cystic carcinoma

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The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

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Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways

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Nuclear overexpression of NAD(P)H:quinone oxidoreductase 1 in Chinese hamster ovary cells increases the cytotoxicity of mitomycin C under aerobic and hypoxic conditions

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Constitutive mRNA expression and protein activity levels of nine ABC efflux transporters in seven permanent cell lines derived from different tissues of rainbow trout (Oncorhynchus mykiss).

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Mitochondrial genome depletion dysregulates bile acid- and paracetamol-induced expression of the transporters Mdr1, Mrp1 and Mrp4 in liver cells

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Subcellular localization and activity of multidrug resistance proteins

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10.1080/01635581.2016.1224369

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27636860%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27636860%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

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