(Q51748947)

11 April 2018

title

An industry perspective on tiered approach to the investigation of metabolites in drug development. (English)

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11 April 2018

author name string

Su-Er W Huskey

1

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11 April 2018

Wenkui Li

2

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James B Mangold

3

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Jimmy Flarakos

4

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11 April 2018

publication date

1 March 2014

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11 April 2018

published in

Bioanalysis

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11 April 2018

volume

6

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issue

5

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page(s)

617-628

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11 April 2018

Qualitative analysis of the role of metabolites in inhibitory drug-drug interactions: literature evaluation based on the metabolism and transport drug interaction database

cites work

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Active metabolites resulting from decarboxylation, reduction and ester hydrolysis of parent drugs

21 January 2018

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Strategies for a comprehensive understanding of metabolism by aldehyde oxidase

21 January 2018

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Perspectives on non-clinical safety evaluation of drug metabolites through the JSOT workshop

21 January 2018

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Pharmacologically active drug metabolites: impact on drug discovery and pharmacotherapy

21 January 2018

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Best practices in a tiered approach to metabolite quantification: views and recommendations of the European Bioanalysis Forum.

21 January 2018

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Meeting report: metabolites in safety testing (MIST) symposium-safety assessment of human metabolites: what's REALLY necessary to ascertain exposure coverage in safety tests?

21 January 2018

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Strategies in quantitative LC-MS/MS analysis of unstable small molecules in biological matrices

21 January 2018

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A liquid chromatography/electrospray ionization mass spectrometry (LC-MS/MS) assay for the determination of irinotecan (CPT-11) and its two major metabolites in human liver microsomal incubations and human plasma samples

21 January 2018

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Simultaneous determination of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate and pipecolic acid by LC-MS/MS for pyridoxine-dependent seizures and folinic acid-responsive seizures.

21 January 2018

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Investigation of EDTA anticoagulant in plasma to improve the throughput of liquid chromatography/tandem mass spectrometric assays

21 January 2018

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Choline in whole blood and plasma: sample preparation and stability

21 January 2018

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Stabilizing drug molecules in biological samples

21 January 2018

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Instability of calcium channel antagonists during sample preparation for LC-MS-MS analysis of serum samples

21 January 2018

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Identifying trends and developing solutions for incurred sample reanalysis failure investigations in a bioanalytical CRO.

21 January 2018

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Systematic LC-MS/MS bioanalytical method development that incorporates plasma phospholipids risk avoidance, usage of incurred sample and well thought-out chromatography

21 January 2018

1 reference

Impact of glucuronide interferences on therapeutic drug monitoring of posaconazole by tandem mass spectrometry.

21 January 2018

1 reference

Studies on the influence of esterase inhibitor to the pharmacokinetic profiles of oseltamivir and oseltamivir carboxylate in rats using an improved LC/MS/MS method

21 January 2018

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Simultaneous determination of caffeic acid phenethyl ester and its metabolite caffeic acid in dog plasma using liquid chromatography tandem mass spectrometry.

21 January 2018

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Stability of caffeic acid phenethyl ester and its fluorinated derivative in rat plasma

21 January 2018

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Dried blood spot sampling in combination with LC-MS/MS for quantitative analysis of small molecules

21 January 2018

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DBS sampling can be used to stabilize prodrugs in drug discovery rodent studies without the addition of esterase inhibitors

21 January 2018

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Liquid extraction surface analysis (LESA) of food surfaces employing chip-based nano-electrospray mass spectrometry.

21 January 2018

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Investigation of figopitant and its metabolites in rat tissue by combining whole-body autoradiography with liquid extraction surface analysis mass spectrometry

21 January 2018

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Automated liquid microjunction surface sampling-HPLC-MS/MS analysis of drugs and metabolites in whole-body thin tissue sections

21 January 2018

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Cross-species comparison of the metabolism and excretion of zoniporide: contribution of aldehyde oxidase to interspecies differences

21 January 2018

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Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications

21 January 2018

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Microproteomics by liquid extraction surface analysis: Application to FFPE tissue to study the fimbria region of tubo-ovarian cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/BIO.14.25

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11 April 2018

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11 April 2018