(Q38066611)

28 August 2017

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title

Strategies for a comprehensive understanding of metabolism by aldehyde oxidase (English)

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28 August 2017

author name string

James Matthew Hutzler

1

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28 August 2017

Ronald Scott Obach

2

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28 August 2017

Deepak Dalvie

3

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28 August 2017

Michael A Zientek

4

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28 August 2017

language of work or name

English

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publication date

12 December 2012

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Expert Opinion on Drug Metabolism & Toxicology

28 August 2017

published in

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28 August 2017

volume

9

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28 August 2017

issue

2

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28 August 2017

page(s)

153-168

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Early ADME in support of drug discovery: the role of metabolic stability studies

28 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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Individual variation in hepatic aldehyde oxidase activity

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Aldehyde oxidase activity and inhibition in hepatocytes and cytosolic fractions from mouse, rat, monkey and human

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Species variation in hepatic aldehyde oxidase activity

21 January 2018

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Aldehyde oxidase: an enzyme of emerging importance in drug discovery

21 January 2018

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Increasing recognition of the importance of aldehyde oxidase in drug development and discovery

21 January 2018

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The role of aldehyde oxidase in drug metabolism

21 January 2018

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Phase I and pharmacokinetic study of BIBX 1382 BS, an epidermal growth factor receptor (EGFR) inhibitor, given in a continuous daily oral administration

21 January 2018

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Cross-species comparison of the metabolism and excretion of zoniporide: contribution of aldehyde oxidase to interspecies differences

21 January 2018

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In silico and in vitro pharmacogenetics: aldehyde oxidase rapidly metabolizes a p38 kinase inhibitor

21 January 2018

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Case report of extensive metabolism by aldehyde oxidase in humans: pharmacokinetics and metabolite profile of FK3453 in rats, dogs, and humans.

21 January 2018

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Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications

21 January 2018

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Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety

21 January 2018

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Synopsis of some recent tactical application of bioisosteres in drug design

21 January 2018

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Mitigating heterocycle metabolism in drug discovery

21 January 2018

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Potent inhibition of human liver aldehyde oxidase by raloxifene

21 January 2018

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Inhibition of xanthine oxidase by allopurinol: a therapeutic option for ischaemia induced pathological processes?

21 January 2018

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Lipophilicity in PK design: methyl, ethyl, futile

21 January 2018

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Substrate SARs in human P450s

21 January 2018

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Compound lipophilicity for substrate binding to human P450s in drug metabolism

21 January 2018

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Discovery and ADMET: Where are we now.

21 January 2018

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Systematic structure modifications of imidazo[1,2-a]pyrimidine to reduce metabolism mediated by aldehyde oxidase (AO).

21 January 2018

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Medicinal chemistry approaches to avoid aldehyde oxidase metabolism

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Quantitative study of the structural requirements of phthalazine/quinazoline derivatives for interaction with human liver aldehyde oxidase

21 January 2018

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Structure-based drug metabolism predictions for drug design.

21 January 2018

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State-of-the-art tools for computational site of metabolism predictions: comparative analysis, mechanistical insights, and future applications

21 January 2018

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Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections.

21 January 2018

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Inhibition of zaleplon metabolism by cimetidine in the human liver: in vitro studies with subcellular fractions and precision-cut liver slices

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Human liver aldehyde oxidase: differential inhibition of oxidation of charged and uncharged substrates

21 January 2018

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Oxidation of Selected Pteridine Derivatives by Mammalian Liver Xanthine Oxidase and Aldehyde Oxidase

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Aldehyde oxidase-catalysed oxidation of methotrexate in the liver of guinea-pig, rabbit and man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Comparison of the toxicity of allyl alcohol, coumarin and menadione in precision-cut rat, guinea-pig, cynomolgus monkey and human liver slices

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Differential time-dependent inactivation of P450 3A4 and P450 3A5 by raloxifene: a key role for C239 in quenching reactive intermediates

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Human liver aldehyde oxidase: inhibition by 239 drugs

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Hydralazine as a selective probe inactivator of aldehyde oxidase in human hepatocytes: estimation of the contribution of aldehyde oxidase to metabolic clearance

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Hydralazine: a potent inhibitor of aldehyde oxidase activity in vitro and in vivo

21 January 2018

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Biotransformation of carbazeran in guinea pig: effect of hydralazine pretreatment

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Commentary: a physiological approach to hepatic drug clearance

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

The impact of single nucleotide polymorphisms on human aldehyde oxidase

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions.

21 January 2018

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Inhibition of human liver aldehyde oxidase: implications for potential drug-drug interactions

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Identification of aldehyde oxidase 1 and aldehyde oxidase homologue 1 as dioxin-inducible genes.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Drug metabolites in safety testing

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Metabolic switching of BILR 355 in the presence of ritonavir. II. Uncovering novel contributions by gut bacteria and aldehyde oxidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Pharmacokinetic and safety evaluation of BILR 355, a second-generation nonnucleoside reverse transcriptase inhibitor, in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.738668

The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Species differences in enantioselective 2-oxidations of RS-8359, a selective and reversible MAO-A inhibitor, and cinchona alkaloids by aldehyde oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Inter-strain variability in aldehyde oxidase activity in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.738668

Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.738668

10.1517/17425255.2013.738668

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

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