(Q51770733)

English

Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure.

scientific article published on 13 December 2010

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scholarly article

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure. (English)

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

protein structure

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Alzheimer's disease

1 reference

based on heuristic

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author name string

Stefanie Hahn

1

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

Tanja Brüning

2

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

Julia Ness

3

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

Eva Czirr

4

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

Sandra Baches

5

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

Harrie Gijsen

6

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

Carsten Korth

7

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

Claus U Pietrzik

8

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

Bruno Bulic

9

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

Sascha Weggen

10

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Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

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publication date

13 December 2010

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Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

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11

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Journal of Neurochemistry

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

116

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Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

3

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Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

385-395

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Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

Probing the biology of Alzheimer's disease in mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Iminoheterocycles as gamma-secretase modulators.

1 reference

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21 January 2018

Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model

1 reference

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21 January 2018

Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation

1 reference

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21 January 2018

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

1 reference

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21 January 2018

Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.

1 reference

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21 January 2018

Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase

1 reference

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21 January 2018

Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

The secretases: enzymes with therapeutic potential in Alzheimer disease

1 reference

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21 January 2018

Alzheimer disease models and human neuropathology: similarities and differences

1 reference

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21 January 2018

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

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21 January 2018

Piperidine-derived gamma-secretase modulators

1 reference

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21 January 2018

Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.

1 reference

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21 January 2018

Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity

1 reference

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21 January 2018

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

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21 January 2018

1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Substrate-targeting gamma-secretase modulators

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Selective modulation of Abeta42 production in Alzheimer's disease: non-steroidal anti-inflammatory drugs and beyond.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Secretion of the Notch-1 Abeta-like peptide during Notch signaling

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Beta-amyloid precursor protein mutants respond to gamma-secretase modulators

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Purine derivatives as potent gamma-secretase modulators

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Piperazinyl pyrimidine derivatives as potent gamma-secretase modulators

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

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21 January 2018

Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.07118.X

21 January 2018

Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice.

1 reference

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21 January 2018

Exploring the chemical space of gamma-secretase modulators.

1 reference

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21 January 2018

Identifiers

10.1111/J.1471-4159.2010.07118.X

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/21091478

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