(Q51779135)

12 April 2018

title

Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited. (English)

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12 April 2018

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11

Alan T Remaley

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12 April 2018

author name string

Federica Basso

1

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12 April 2018

Lita A Freeman

2

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12 April 2018

Carol Ko

3

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12 April 2018

Charles Joyce

4

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12 April 2018

Marcelo J Amar

5

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12 April 2018

Robert D Shamburek

6

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12 April 2018

Terese Tansey

7

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12 April 2018

Fairwell Thomas

8

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12 April 2018

Justina Wu

9

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12 April 2018

Beverly Paigen

10

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12 April 2018

Silvia Santamarina-Fojo

12

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12 April 2018

H Bryan Brewer

13

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12 April 2018

publication date

23 October 2006

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12 April 2018

Journal of Lipid Research

published in

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12 April 2018

volume

48

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12 April 2018

issue

1

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12 April 2018

page(s)

114-126

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12 April 2018

Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

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Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively

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Beta-sitosterolemia and xanthomatosis. A newly described lipid storage disease in two sisters

21 January 2018

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Inhibition of cholesterol absorption by HMG-CoA reductase inhibitor.

21 January 2018

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β-Sitosterolemia and Xanthomatosis

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Abnormal metabolism of shellfish sterols in a patient with sitosterolemia and xanthomatosis

21 January 2018

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Genetic basis of sitosterolemia

21 January 2018

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Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

21 January 2018

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Localization of ABCG5 and ABCG8 proteins in human liver, gall bladder and intestine

21 January 2018

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A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol

21 January 2018

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Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

21 January 2018

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ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion

21 January 2018

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ABCG5 and ABCG8 are expressed in gallbladder epithelial cells

21 January 2018

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Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor.

21 January 2018

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Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice

21 January 2018

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High-level expression of ABCG5 and ABCG8 attenuates diet-induced hypercholesterolemia and atherosclerosis in Ldlr-/- mice

21 January 2018

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Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

21 January 2018

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Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis

21 January 2018

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The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice

21 January 2018

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ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice

21 January 2018

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Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations

21 January 2018

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Quantitative assessment of atherosclerotic lesions in mice

21 January 2018

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Inhibition of cholesterol absorption by SCH 58053 in the mouse is not mediated via changes in the expression of mRNA for ABCA1, ABCG5, or ABCG8 in the enterocyte

21 January 2018

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Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption

21 January 2018

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Effect of ezetimibe on the in vivo kinetics of apoB-48 and apoB-100 in men with primary hypercholesterolemia.

21 January 2018

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Thematic review series: patient-oriented research. What we have learned about VLDL and LDL metabolism from human kinetics studies

21 January 2018

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Effect of rosuvastatin on hepatic production of apolipoprotein B-containing lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia

21 January 2018

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Hepatic overexpression of sterol carrier protein-2 inhibits VLDL production and reciprocally enhances biliary lipid secretion

21 January 2018

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ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from murine hepatocytes

21 January 2018

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The HMG-CoA reductase inhibitor atorvastatin increases the fractional clearance rate of postprandial triglyceride-rich lipoproteins in miniature pigs.

21 January 2018

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Rosuvastatin reduces plasma lipids by inhibiting VLDL production and enhancing hepatobiliary lipid excretion in ApoE*3-leiden mice

21 January 2018

1 reference

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Role of cholesterol ester mass in regulation of secretion of ApoB100 lipoprotein particles by hamster hepatocytes and effects of statins on that relationship

21 January 2018

1 reference

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A novel inhibitor of oxidosqualene:lanosterol cyclase inhibits very low-density lipoprotein apolipoprotein B100 (apoB100) production and enhances low-density lipoprotein apoB100 catabolism through marked reduction in hepatic cholesterol content

21 January 2018

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Lipoprotein heterogeneity and apolipoprotein B metabolism

21 January 2018

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Microsomal triglyceride transfer protein -493T variant reduces IDL plus LDL apoB production and the plasma concentration of large LDL particles

21 January 2018

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HOE 402 lowers serum cholesterol levels by reducing VLDL-lipid production, and not by induction of the LDL receptor, and reduces atherosclerosis in wild-type and LDL receptor-deficient mice

21 January 2018

1 reference

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Dietary plant stanol esters reduce VLDL cholesterol secretion and bile saturation in apolipoprotein E*3-Leiden transgenic mice

21 January 2018

1 reference

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Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice

21 January 2018

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Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver

21 January 2018

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Fatty acids differentially regulate hepatic cholesteryl ester formation and incorporation into lipoproteins in the liver of the mouse

21 January 2018

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Endogenous cholesterol synthesis is associated with VLDL-2 apoB-100 production in healthy humans.

21 January 2018

1 reference

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Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600353-JLR200

Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600353-JLR200

Cholesterol and hepatic lipoprotein assembly and secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600353-JLR200

Ezetimibe, a potent cholesterol absorption inhibitor, inhibits the development of atherosclerosis in ApoE knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600353-JLR200

10.1194/JLR.M600353-JLR200

21 January 2018

Identifiers

DOI

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12 April 2018

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12 April 2018