(Q51796054)

English

Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs.

scientific article published on 16 July 2007

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scholarly article

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Europe PubMed Central

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2 January 2020

Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs (English)

1 reference

Europe PubMed Central

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2 January 2020

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Andrew D Nguyen

1

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2 January 2020

author name string

Jeffrey G McDonald

2

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2 January 2020

Richard K Bruick

3

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2 January 2020

Russell A DeBose-Boyd

4

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2 January 2020

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publication date

16 July 2007

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2 January 2020

number of pages

11

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Journal of Biological Chemistry

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2 January 2020

282

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2 January 2020

27436-27446

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2 January 2020

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2 January 2020

Regulation of the mevalonate pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Protein sensors for membrane sterols

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Transport-Dependent Proteolysis of SREBP

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Membrane-bound enzymes of cholesterol synthesis from lanosterol

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Steroids, triterpenoids and molecular oxygen

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Hydroxylation of HIF-1: oxygen sensing at the molecular level

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Purification and characterization of hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Selective inhibition of mammalian lanosterol 14 alpha-demethylase by RS-21607 in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Cellular cholesterol efflux mediated by cyclodextrins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Oxygen sensing by HIF hydroxylases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Analysis of the effect of aging on the response to hypoxia by cDNA microarray

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Genome-wide expression analysis using microarray identified complex signaling pathways modulated by hypoxia in nasopharyngeal carcinoma.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Transcriptional downregulation of sterol metabolism genes in murine liver exposed to acute hypobaric hypoxia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704976200

21 January 2018

Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells.

1 reference

19 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/S0021-9258(19)84879-2

Identifiers

10.1074/JBC.M704976200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635920%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635920%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

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