(Q51796573)

12 April 2018

title

Amplification of the gene for SCAP, coupled with Insig-1 deficiency, confers sterol resistance in mutant Chinese hamster ovary cells. (English)

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12 April 2018

author name string

Peter C W Lee

1

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12 April 2018

Pingsheng Liu

2

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12 April 2018

Wei-Ping Li

3

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12 April 2018

Russell A Debose-Boyd

4

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12 April 2018

publication date

22 June 2007

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12 April 2018

Journal of Lipid Research

published in

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12 April 2018

volume

48

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12 April 2018

issue

9

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12 April 2018

page(s)

1944-1954

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12 April 2018

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

cites work

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https://api.crossref.org/works/10.1194%2FJLR.M700225-JLR200

Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain

21 January 2018

1 reference

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Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700225-JLR200

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

21 January 2018

1 reference

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Regulation of the mevalonate pathway

21 January 2018

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https://api.crossref.org/works/10.1194%2FJLR.M700225-JLR200

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

21 January 2018

1 reference

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Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain

21 January 2018

1 reference

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Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum

21 January 2018

1 reference

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Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

21 January 2018

1 reference

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Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700225-JLR200

Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

21 January 2018

1 reference

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

21 January 2018

1 reference

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The sterol-sensing domain: multiple families, a unique role?

21 January 2018

1 reference

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Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

21 January 2018

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Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation

21 January 2018

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Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol

21 January 2018

1 reference

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Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700225-JLR200

Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.

21 January 2018

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Transport-Dependent Proteolysis of SREBP

21 January 2018

1 reference

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Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2.

21 January 2018

1 reference

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Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700225-JLR200

Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700225-JLR200

Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic

21 January 2018

1 reference

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Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700225-JLR200

Caveolin, cholesterol, and lipid bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700225-JLR200

Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700225-JLR200

Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700225-JLR200

Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700225-JLR200

Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells.

21 January 2018

1 reference

19 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/S0021-9258(19)84879-2

Identifiers

DOI

10.1194/JLR.M700225-JLR200

1 reference

12 April 2018

1 reference

12 April 2018