(Q51797175)

English

Partial agonist actions of aripiprazole and the candidate antipsychotics S33592, bifeprunox, N-desmethylclozapine and preclamol at dopamine D(2L) receptors are modified by co-transfection of D(3) receptors: potential role of heterodimer formation.

scientific article published on 26 May 2007

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scholarly article

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17532788

Partial agonist actions of aripiprazole and the candidate antipsychotics S33592, bifeprunox, N-desmethylclozapine and preclamol at dopamine D(2L) receptors are modified by co-transfection of D(3) receptors: potential role of heterodimer formation. (English)

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17532788

4

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17532788

author name string

Francesca Novi

1

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17532788

Mark J Millan

2

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17532788

Giovanni U Corsini

3

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17532788

language of work or name

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publication date

26 May 2007

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17532788

Journal of Neurochemistry

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Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17532788

102

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Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17532788

4

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Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17532788

1410-1424

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17532788

Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons.

1 reference

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21 January 2018

The novel antipsychotic aripiprazole is a partial agonist at short and long isoforms of D2 receptors linked to the regulation of adenylyl cyclase activity and prolactin release

1 reference

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21 January 2018

Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function

1 reference

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21 January 2018

Contrasting contribution of 5-hydroxytryptamine 1A receptor activation to neurochemical profile of novel antipsychotics: frontocortical dopamine and hippocampal serotonin release in rat brain

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Adenylylcyclase supersensitization in mu-opioid receptor-transfected Chinese hamster ovary cells following chronic opioid treatment

1 reference

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21 January 2018

Domain swapping in the human histamine H1 receptor

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21 January 2018

Antipsychotic-like vs cataleptogenic actions in mice of novel antipsychotics having D2 antagonist and 5-HT1A agonist properties

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D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N

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Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa

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Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase

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21 January 2018

Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors

1 reference

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21 January 2018

Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist

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21 January 2018

Agonist occupation of an alpha2A-adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

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21 January 2018

Basal signaling activity of human dopamine D2L receptor demonstrated with an ecdysone-inducible mammalian expression system

1 reference

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21 January 2018

New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D(2)-receptor and serotonin 5-HT(1A)-receptor affinities

1 reference

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21 January 2018

Effects of reciprocal chimeras between the C-terminal portion of third intracellular loops of the human dopamine D2 and D3 receptors

1 reference

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21 January 2018

Functional coupling of the human dopamine D2 receptor with G alpha i1, G alpha i2, G alpha i3 and G alpha o G proteins: evidence for agonist regulation of G protein selectivity

1 reference

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21 January 2018

Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties

1 reference

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21 January 2018

Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes

1 reference

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Mechanism of new antipsychotic medications: occupancy is not just antagonism

1 reference

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21 January 2018

The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer.

1 reference

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21 January 2018

Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation

1 reference

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21 January 2018

Distribution of dopamine D3 receptor expressing neurons in the human forebrain: comparison with D2 receptor expressing neurons

1 reference

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Autoradiographic localisation of D3-dopamine receptors in the human brain using the selective D3-dopamine receptor agonist (+)-[3H]PD 128907.

1 reference

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21 January 2018

Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors

1 reference

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21 January 2018

Strategy for modulation of central dopamine transmission based on the partial agonist concept in schizophrenia therapy

1 reference

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21 January 2018

The ants go marching two by two: oligomeric structure of G-protein-coupled receptors.

1 reference

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21 January 2018

In vivo effects of aripiprazole on cortical and striatal dopaminergic and serotonergic function

1 reference

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21 January 2018

Dopamine autoreceptor regulation of release and uptake in mouse brain slices in the absence of D(3) receptors

1 reference

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21 January 2018

Dopamine D3 receptor as a therapeutic target for antipsychotic and antiparkinsonian drugs

1 reference

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21 January 2018

Dopamine D3 receptor antagonists as therapeutic agents

1 reference

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21 January 2018

Efficacy and safety of aripiprazole vs. haloperidol for long-term maintenance treatment following acute relapse of schizophrenia

1 reference

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21 January 2018

Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins

1 reference

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21 January 2018

G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation.

1 reference

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21 January 2018

Aripiprazole: pharmacology, efficacy, safety and tolerability

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21 January 2018

Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists.

1 reference

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21 January 2018

Antipsychotic properties of the partial dopamine agonist (-)-3-(3-hydroxyphenyl)-N-n-propylpiperidine(preclamol) in schizophrenia

1 reference

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21 January 2018

Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes

1 reference

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21 January 2018

Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal

1 reference

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21 January 2018

Aripiprazole, a novel antipsychotic drug, preferentially increases dopamine release in the prefrontal cortex and hippocampus in rat brain

1 reference

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21 January 2018

N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarinic receptors

1 reference

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21 January 2018

Dopamine partial agonists: a new class of antipsychotic

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21 January 2018

Progress in developing D3 dopamine receptor ligands as potential therapeutic agents for neurological and neuropsychiatric disorders

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Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors

1 reference

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21 January 2018

Potent activation of dopamine D3/D2 heterodimers by the antiparkinsonian agents, S32504, pramipexole and ropinirole

1 reference

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21 January 2018

The impact of G-protein-coupled receptor hetero-oligomerization on function and pharmacology

1 reference

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21 January 2018

Serotonin receptors: their key role in drugs to treat schizophrenia

1 reference

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21 January 2018

Cooperative conformational changes in a G-protein-coupled receptor dimer, the leukotriene B(4) receptor BLT1.

1 reference

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21 January 2018

The role of dopamine D3 compared with D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats

1 reference

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21 January 2018

Associative and limbic regions of monkey striatum express high levels of dopamine D3 receptors: effects of MPTP and dopamine agonist replacement therapies.

1 reference

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21 January 2018

Diminished catalepsy and dopamine metabolism distinguish aripiprazole from haloperidol or risperidone

1 reference

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21 January 2018

Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

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Aripiprazole, an antipsychotic with a novel mechanism of action, and risperidone vs placebo in patients with schizophrenia and schizoaffective disorder

1 reference

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21 January 2018

D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum

1 reference

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21 January 2018

Atypical antipsychotics: are some more atypical than others?

1 reference

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21 January 2018

Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity

1 reference

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21 January 2018

D2/D3 dopamine receptor heterodimers exhibit unique functional properties

1 reference

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21 January 2018

Up-regulation of D3 dopamine receptor mRNA in the nucleus accumbens of human cocaine fatalities.

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21 January 2018

Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.

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21 January 2018

Functional selectivity, ligand-directed trafficking, conformation-specific agonism: what's in a name?

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21 January 2018

Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor

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21 January 2018

The dopamine D3 receptor: a therapeutic target for the treatment of neuropsychiatric disorders

1 reference

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21 January 2018

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- d -aspartate receptor activity

1 reference

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21 January 2018

D3 dopamine receptor mRNA is widely expressed in the human brain

1 reference

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21 January 2018

Aripiprazole's low intrinsic activities at human dopamine D2L and D2S receptors render it a unique antipsychotic

1 reference

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21 January 2018

Partial dopamine agonists and dopaminergic stabilizers, in the treatment of psychosis

1 reference

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21 January 2018

Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes

1 reference

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21 January 2018

A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers

1 reference

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21 January 2018

Interaction of bivalent ligand KDN21 with heterodimeric delta-kappa opioid receptors in human embryonic kidney 293 cells

1 reference

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21 January 2018

Efficient functional coupling of the human D3 dopamine receptor to G(o) subtype of G proteins in SH-SY5Y cells

1 reference

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21 January 2018

Dopamine D1 receptor augmentation of D3 receptor action in rat aortic or mesenteric vascular smooth muscles

1 reference

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21 January 2018

Rhodopsin dimers in native disc membranes

1 reference

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21 January 2018

Identifiers

10.1111/J.1471-4159.2007.04660.X

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17532788

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17532788

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