(Q51807216)

12 April 2018

title

De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer. (English)

1 reference

12 April 2018

main subject

endoplasmic reticulum

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author name string

Saber Tadros

1

1 reference

12 April 2018

Surendra K Shukla

2

1 reference

12 April 2018

Ryan J King

3

1 reference

12 April 2018

Venugopal Gunda

4

1 reference

12 April 2018

Enza Vernucci

5

1 reference

12 April 2018

Jaime Abrego

6

1 reference

12 April 2018

Nina V Chaika

7

1 reference

12 April 2018

Fang Yu

8

1 reference

12 April 2018

Audrey J Lazenby

9

1 reference

12 April 2018

Lyudmyla Berim

10

1 reference

12 April 2018

Jean Grem

11

1 reference

12 April 2018

Aaron R Sasson

12

1 reference

12 April 2018

Pankaj K Singh

13

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12 April 2018

language of work or name

English

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publication date

15 August 2017

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12 April 2018

published in

Cancer Research

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12 April 2018

volume

77

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12 April 2018

issue

20

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12 April 2018

page(s)

5503-5517

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12 April 2018

MUC1-mediated metabolic alterations regulate response to radiotherapy in pancreatic cancer

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2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer

2 November 2018

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2 November 2018

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Stem cell profiling in head and neck cancer reveals an Oct-4 expressing subpopulation with properties of chemoresistance

2 November 2018

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2 November 2018

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Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer

2 November 2018

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2 November 2018

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2 November 2018

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MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer

2 November 2018

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Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism

2 November 2018

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

Intrinsic gemcitabine resistance in a novel pancreatic cancer cell line is associated with cancer stem cell-like phenotype

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

Targeting cancer metabolism: a therapeutic window opens

2 November 2018

1 reference

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2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1.

2 November 2018

1 reference

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2 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

Validation of the 6th edition AJCC Pancreatic Cancer Staging System: report from the National Cancer Database

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

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2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

Identification of bioactive molecules by adipogenesis profiling of organic compounds

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

Synthesis and antitumor activity of an inhibitor of fatty acid synthase

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

Fatty acid synthesis: a potential selective target for antineoplastic therapy

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

An established pre-adipose cell line and its differentiation in culture.

2 November 2018

1 reference

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Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5645242

Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines

2 November 2018

1 reference

12 December 2020

OA-519 (fatty acid synthase) as an independent predictor of pathologic state in adenocarcinoma of the prostate

1 reference

12 December 2020

Regulation of phosphorylation of deoxycytidine and 2',2'-difluorodeoxycytidine (gemcitabine); effects of cytidine 5'-triphosphate and uridine 5'-triphosphate in relation to chemosensitivity for 2',2'-difluorodeoxycytidine

1 reference

12 December 2020

Immunohistochemical expression and prognostic significance of fatty acid synthase in pancreatic carcinoma

1 reference

12 December 2020

10.1158/0008-5472.CAN-16-3062

Identifiers

DOI

1 reference

12 April 2018

PMC publication ID

5645242

0 references

1 reference

12 April 2018