(Q51809883)

12 April 2018

title

Cell painting with an engineered EPCR to augment the protein C system. (English)

1 reference

12 April 2018

author name string

Eveline A M Bouwens

series ordinal

1

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12 April 2018

Fabian Stavenuiter

series ordinal

2

1 reference

12 April 2018

Laurent O Mosnier

series ordinal

3

1 reference

12 April 2018

publication date

13 August 2015

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12 April 2018

Thrombosis and Haemostasis

published in

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12 April 2018

volume

114

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12 April 2018

issue

6

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12 April 2018

page(s)

1144-1155

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12 April 2018

Platelet endothelial cell adhesion molecule targeted oxidant-resistant mutant thrombomodulin fusion protein with enhanced potency in vitro and in vivo

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22 May 2018

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Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3.

22 May 2018

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Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children

22 May 2018

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Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor.

22 May 2018

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Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46.

22 May 2018

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Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity

22 May 2018

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Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis

22 May 2018

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Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice

22 May 2018

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Protein C anticoagulant system--anti-inflammatory effects

22 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

The occupancy of endothelial protein C receptor by its ligand modulates the par-1 dependent signaling specificity of coagulation proteases

22 May 2018

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Cytoprotective protein C pathways and implications for stroke and neurological disorders

22 May 2018

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Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.

22 May 2018

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Regulation of the protein C anticoagulant and antiinflammatory pathways

22 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

The cytoprotective effects of addition of activated protein C into preservation solution on small-for-size grafts in rats

22 May 2018

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The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications

22 May 2018

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Proteases display biased agonism at protease-activated receptors: location matters!

22 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Caveolae are required for protease-selective signaling by protease-activated receptor-1.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

22 May 2018

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Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

The cytoprotective protein C pathway

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

A soluble tissue factor-annexin V chimeric protein has both procoagulant and anticoagulant properties

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Modified cell ELISA to determine the solubilization of cell surface proteins: Applications in GPI-anchored protein purification

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Differential insertion of GPI-anchored GFPs into lipid rafts of live cells.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

The alpha v beta 3 integrin as a tumor homing ligand for lymphocytes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Expression of endothelial protein C receptor and thrombomodulin in the intestinal tissue of patients with inflammatory bowel disease

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Endothelial cell protein C receptor plays an important role in protein C activation in vivo

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Metalloproteolytic release of endothelial cell protein C receptor

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Protein transfer of preformed MHC-peptide complexes sensitizes target cells to T cell cytolysis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Construction, purification, and functional incorporation on tumor cells of glycolipid-anchored human B7-1 (CD80).

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Fusion of sequence elements from non-anchored proteins to generate a fully functional signal for glycophosphatidylinositol membrane anchor attachment

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Protein C system defects inflicted by the malaria parasite protein PfEMP1 can be overcome by a soluble EPCR variant.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Protective effects of transgenic human endothelial protein C receptor expression in murine models of transplantation.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Co-immobilization of urokinase and thrombomodulin on islet surfaces by poly(ethylene glycol)-conjugated phospholipid.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Liposomal formulations of thrombomodulin increase engraftment after intraportal islet transplantation

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Endothelial protein C receptor plasma levels increase in chronic liver disease, while thrombomodulin plasma levels increase only in hepatocellular carcinoma

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

A simplified method for the preparation of detergent-free lipid rafts

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Glycosyl phosphatidylinositol anchor

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

Dysfunction of Endothelial Protein C Activation in Severe Meningococcal Sepsis

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053618

sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove

30 November 2018

1 reference

12 December 2020

Activated protein C based therapeutic strategies in chronic diseases

1 reference

12 December 2020

The endothelial cell protein C receptor

1 reference

12 December 2020

Haplotypes of the EPCR gene, plasma sEPCR levels and the risk of deep venous thrombosis

1 reference

12 December 2020

The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis

1 reference

12 December 2020

Graft protein C entrapment is associated with reduced phagocyte activation during reperfusion in human liver transplantation

1 reference

12 December 2020

EPCR encryption induces cellular APC resistance

1 reference

12 December 2020

Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes

1 reference

12 December 2020

In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium

1 reference

12 December 2020

Identifiers

DOI

10.1160/TH15-01-0079

1 reference

12 April 2018

PMCID

5053618

1 reference

12 April 2018

PubMed ID

26272345

1 reference

12 April 2018