(Q24617126)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

2

1 reference

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6 February 2020

John H Griffin

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

20

Martin Hauer-Jensen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

author name string

Hartmut Geiger

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Edward J Kerschen

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Kalpana J Nattamai

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Irene Hernandez

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Hai Po H Liang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Jose Á Fernández

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Jose A Cancelas

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Marnie A Ryan

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Olga Kustikova

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Qiang Fu

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Junru Wang

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Louis M Fink

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Karl-Uwe Petersen

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Daohong Zhou

16

1 reference

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6 February 2020

Christopher Baum

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Hartmut Weiler

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Axel Schambach

11

1 reference

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6 February 2020

language of work or name

English

0 references

publication date

1 July 2012

1 reference

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6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

volume

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

page(s)

1123-1129

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state

6 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

The cytoprotective protein C pathway

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

"Stemness": transcriptional profiling of embryonic and adult stem cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Solulin increases clot stability in whole blood from humans and dogs with hemophilia

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Factor XI-deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

The thrombomodulin analog Solulin promotes reperfusion and reduces infarct volume in a thrombotic stroke model

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Regulation of inflammation by the protein C system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Extracellular histones are major mediators of death in sepsis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Determination of sample sizes for demonstrating efficacy of radiation countermeasures

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Selective irradiation of the vascular endothelium has no effect on the survival of murine intestinal crypt stem cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Ionizing radiation induces apoptosis and inhibits neuronal differentiation in rat neural stem cells via the c-Jun NH2-terminal kinase (JNK) pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. A potential rapid mechanism for modulation of coagulation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Biological consequences of thrombin receptor deficiency in mice.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Estimation of surface area from vertical sections.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver.

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a TH2-skewed immune response

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Inactivation of thrombomodulin by ionizing radiation in a cell-free system: possible implications for radiation responses in vascular endothelium

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

The shape of thrombomodulin and interactions with thrombin as determined by electron microscopy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Role of the thrombin receptor in development and evidence for a second receptor.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491776

Characterization of a mouse model for thrombomodulin deficiency

28 November 2018

1 reference

12 December 2020

Mouse models of thrombosis: thrombomodulin

1 reference

12 December 2020

A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse

1 reference

12 December 2020

Optimal interfraction interval to minimize small bowel radiation injury in treatment regimens with two fractions per day: an experimental study in a rat model

1 reference

12 December 2020

Human neutrophils synthesize thrombomodulin that does not promote thrombin-dependent protein C activation

1 reference

12 December 2020

Soluble thrombomodulin is antithrombotic in the presence of neutralising antibodies to protein C and reduces circulating activated protein C levels in primates

1 reference

12 December 2020

Immunohistologic labeling of murine endothelium

1 reference

12 December 2020

Targeting of transgene expression to the vascular endothelium of mice by homologous recombination at the thrombomodulin locus

1 reference

12 December 2020

Quantitation of a murine lung endothelial cell protein, P112, with a double monoclonal antibody assay

1 reference

12 December 2020

Phase I study of Solulin, a novel recombinant soluble human thrombomodulin analogue

1 reference

12 December 2020

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C

1 reference

12 December 2020

Recombinant soluble human thrombomodulin: a randomized, blinded assessment of prevention of venous thrombosis and effects on hemostatic parameters in a rat model

1 reference

12 December 2020

Elements of the primary structure of thrombomodulin required for efficient thrombin-activable fibrinolysis inhibitor activation

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.2813

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 February 2020

1001141303

0 references

Fatcat ID

release_mekxjmzajfeh3mv575oe5ld2vq

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/mekxjmzajfeh3mv575oe5ld2vq

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

22729286

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286%20AND%20SRC:MED&resulttype=core&format=json