(Q51810799)

12 April 2018

title

Murine thrombin lacks Na+ activation but retains high catalytic activity. (English)

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12 April 2018

author name string

Leslie A Bush

series ordinal

1

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12 April 2018

Ryan W Nelson

series ordinal

2

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12 April 2018

Enrico Di Cera

series ordinal

3

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12 April 2018

language of work or name

English

0 references

publication date

20 January 2006

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12 April 2018

Journal of Biological Chemistry

published in

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12 April 2018

volume

281

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12 April 2018

issue

11

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12 April 2018

page(s)

7183-7188

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12 April 2018

Thrombin is a Na(+)-activated enzyme

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

A structural perspective on enzymes activated by monovalent cations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC). Sodium ion in the APC crystal structure is coordinated to four carbonyl groups from two separate loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Na+ site in blood coagulation factor IXa: effect on catalysis and factor VIIIa binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Sodium binding site of factor Xa: role of sodium in the prothrombinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Molecular dissection of Na+ binding to thrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Residue Asp-189 controls both substrate binding and the monovalent cation specificity of thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Redesigning the monovalent cation specificity of an enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Unexpected crucial role of residue 225 in serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Partial characterization of vertebrate prothrombin cDNAs: amplification and sequence analysis of the B chain of thrombin from nine different species

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Crystal structure of the thrombin mutant D221A/D222K: the Asp222:Arg187 ion-pair stabilizes the fast form.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Prothrombin deficiency results in embryonic and neonatal lethality in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Thrombin signalling and protease-activated receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Familial multiple coagulation factor deficiencies: new biologic insight from rare genetic bleeding disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Energetic and structural consequences of perturbing Gly-193 in the oxyanion hole of serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Dissecting substrate recognition by thrombin using the inactive mutant S195A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Theory of allosteric effects in serine proteases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

An allosteric switch controls the procoagulant and anticoagulant activities of thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Mutation of W215 compromises thrombin cleavage of fibrinogen, but not of PAR-1 or protein C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Molecular mechanisms of thrombin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Profiling serine protease substrate specificity with solution phase fluorogenic peptide microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

The critical role of the 185-189-loop in the factor Xa interaction with Na+ and factor Va in the prothrombinase complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Prothrombin Salakta: substitution of glutamic acid-466 by alanine reduces the fibrinogen clotting activity and the esterase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Replacement of thrombin residue G184 with Lys or Arg fails to mimic Na+ binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Structural replacement of active site monovalent cations by the epsilon-amino group of lysine in the ATPase fragment of bovine Hsc70

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

A dual thrombin receptor system for platelet activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

PAR3 is a cofactor for PAR4 activation by thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Thrombin and platelet activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

The antithrombin P1 residue is important for target proteinase specificity but not for heparin activation of the serpin. Characterization of P1 antithrombin variants with altered proteinase specificity but normal heparin activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Crystal structure of human alpha-thrombin complexed with hirugen and p-amidinophenylpyruvate at 1.6 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

New inhibitors of thrombin and other trypsin-like proteases: hydrogen bonding of an aromatic cyano group with a backbone amide of the P1 binding site replaces binding of a basic side chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

Thrombin inhibitors identified by computer-assisted multiparameter design

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512082200

21 January 2018

Identifiers

DOI

10.1074/JBC.M512082200

1 reference

12 April 2018

1 reference

12 April 2018