(Q51960672)

19 April 2018

title

Impaired T-cell development in the absence of Vav1 and Itk. (English)

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19 April 2018

author

Nicole Boucheron

2

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19 April 2018

Josef Penninger

4

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19 April 2018

Wilfried Ellmeier

5

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19 April 2018

author name string

Julia Raberger

1

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19 April 2018

Shinya Sakaguchi

3

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19 April 2018

language of work or name

English

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publication date

1 December 2008

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19 April 2018

European Journal of Immunology

published in

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19 April 2018

volume

38

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19 April 2018

issue

12

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19 April 2018

page(s)

3530-3542

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19 April 2018

Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

cites work

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

What is the importance of the immunological synapse?

21 January 2018

1 reference

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Molecular controls of antigen receptor clustering and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Vav-family proteins in T-cell signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Cbl-b regulates the CD28 dependence of T-cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

TEC-family kinases: regulators of T-helper-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Identification of Itk/Tsk Src homology 3 domain ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Tec kinases, actin, and cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Tec family kinases in T lymphocyte development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Itk is not essential for CD28 signaling in naive T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Tec family kinases modulate thresholds for thymocyte development and selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Activation events during thymic selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

CD69 expression during selection and maturation of CD4+8+ thymocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

How many thymocytes audition for selection?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

ITK and IL-15 support two distinct subsets of CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Functional hierarchy of the N-terminal tyrosines of SLP-76.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Differential role of SLP-76 domains in T cell development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Naive and innate memory phenotype CD4+ T cells have different requirements for active Itk for their development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

Commentary Vav-1 and T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

7 January 2021

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

7 January 2021

Mutation of Tec family kinases alters T helper cell differentiation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

7 January 2021

Subtle defects in pre-TCR signaling in the absence of the Tec kinase Itk

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

7 January 2021

Differential requirement for SLP-76 domains in T cell development and function

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838388

7 January 2021

Identifiers

DOI

10.1002/EJI.200838388

1 reference

19 April 2018

1 reference

19 April 2018