Wikidata

(Q5205770)

English

Chromatin licensing and DNA replication factor 1

mammalian protein found in Homo sapiens

  • Double parked, Drosophila, homolog of
  • DUP
  • Double parked homolog
  • CDT1
  • DNA replication factor Cdt1
In more languages

Statements

molecular function
protein binding
determination method
IPI
18 references
retrieved
8 April 2019
stated in
Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture
GOA
curator
UniProt
UniProt protein ID
Q9H211
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
retrieved
8 April 2019
stated in
Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression
GOA
curator
UniProt
UniProt protein ID
Q9H211
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
retrieved
8 April 2019
stated in
USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication
GOA
curator
UniProt
UniProt protein ID
Q9H211
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
retrieved
8 April 2019
stated in
A WD-repeat protein stabilizes ORC binding to chromatin
GOA
curator
UniProt
UniProt protein ID
Q9H211
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
retrieved
8 April 2019
stated in
Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
retrieved
8 April 2019
stated in
Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
retrieved
8 April 2019
stated in
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
retrieved
8 April 2019
stated in
Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
retrieved
8 April 2019
stated in
Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
retrieved
8 April 2019
stated in
Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
retrieved
8 April 2019
stated in
The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
retrieved
8 April 2019
stated in
Self-assembling protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
retrieved
8 April 2019
stated in
Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
retrieved
8 April 2019
stated in
Pooled-matrix protein interaction screens using Barcode Fusion Genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
retrieved
8 April 2019
stated in
JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
retrieved
8 April 2019
stated in
Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IPI
cell component
nucleus
determination method
IDA
IEA
6 references
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H211
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H211&geneProductId=UniProtKB:Q9H211
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H211&geneProductId=UniProtKB:Q9H211
determination method
IEA
retrieved
24 April 2018
stated in
Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression
GOA
curator
UniProt
UniProt protein ID
Q9H211
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H211&geneProductId=UniProtKB:Q9H211
determination method
IDA
retrieved
24 April 2018
stated in
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
GOA
curator
UniProt
UniProt protein ID
Q9H211
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H211&geneProductId=UniProtKB:Q9H211
determination method
IDA
retrieved
24 April 2018
stated in
The histone demethylase LSD1/KDM1A promotes the DNA damage response
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H211&geneProductId=UniProtKB:Q9H211
determination method
IDA
retrieved
24 April 2018
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H211&geneProductId=UniProtKB:Q9H211
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H211
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IEA
retrieved
8 April 2019
stated in
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
GOA
curator
UniProt
UniProt protein ID
Q9H211
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IDA
retrieved
8 April 2019
stated in
Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression
GOA
curator
UniProt
UniProt protein ID
Q9H211
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IDA
retrieved
8 April 2019
stated in
The histone demethylase LSD1/KDM1A promotes the DNA damage response
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IDA
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H211
determination method
IBA
biological process
Gene Atlas image
PBB GE CDT1 209832 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

 
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