(Q24301758)

DNA replication checkpoint signaling

GOA release 2020-03-11

1 reference

Journal of Biological Chemistry

GOA release 2020-03-11

Jeanette Gowen Cook

1

Jeanette Gowen

Cook

1 reference

20 April 2024

Dawn A D Chasse

series ordinal

2

author given names

Dawn A D

author last names

Chasse

1 reference

20 April 2024

Joseph R Nevins

series ordinal

3

author given names

Joseph R

author last names

Nevins

1 reference

20 April 2024

language of work or name

English

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publication date

5 March 2004

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published in

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volume

279

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issue

10

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page(s)

9625-33

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cites work

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Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs

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Identification of Tah11/Sid2 as the ortholog of the replication licensing factor Cdt1 in Saccharomyces cerevisiae.

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The Cdt1 protein is required to license DNA for replication in fission yeast

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Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

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XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis

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Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast

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G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus

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Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase

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Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1

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Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

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Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6

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Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication

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Mammalian Orc1 protein is selectively released from chromatin and ubiquitinated during the S-to-M transition in the cell division cycle

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The ORC1 cycle in human cells: I. cell cycle-regulated oscillation of human ORC1.

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A p53-dependent checkpoint pathway prevents rereplication

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Control of DNA replication and chromosome ploidy by geminin and cyclin A

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Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

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The Cdc6p nucleotide-binding motif is required for loading mcm proteins onto chromatin

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The essential role of Saccharomyces cerevisiae CDC6 nucleotide-binding site in cell growth, DNA synthesis, and Orc1 association

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The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells

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Geminin, an inhibitor of DNA replication, is degraded during mitosis

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Analysis of Cdc6 function in the assembly of mammalian prereplication complexes

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Analysis of chromatin structure by in vivo formaldehyde cross-linking.

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Distinct roles for E2F proteins in cell growth control and apoptosis

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A simplified system for generating recombinant adenoviruses

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Identification and characterization of a mouse homolog to yeast Cdc6p

21 January 2018

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An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast

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Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders.

21 January 2018

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Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

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Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint

21 January 2018

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Cell type-specific responses of human cells to inhibition of replication licensing

21 January 2018

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Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311933200

The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311933200

The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase

21 January 2018

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The regulation of E2F by pRB-family proteins

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The Rb/E2F pathway and cancer

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Cell cycle-regulated proteolysis of mitotic target proteins

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311933200

Redundant control of rereplication in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311933200

Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311933200

Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311933200

The roles of the MCM, ORC, and Cdc6 proteins in determining the replication competence of chromatin in quiescent cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311933200

Expression, nuclear localization and interactions of human MCM/P1 proteins

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311933200

A human protein related to yeast Cdc6p

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311933200

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311933200

DNA polymerase alpha associated protein P1, a murine homolog of yeast MCM3, changes its intranuclear distribution during the DNA synthetic period.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311933200

inferred from DOI database lookup

7 January 2021

based on heuristic

p65cdc18 plays a major role controlling the initiation of DNA replication in fission yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311933200