(Q27658141)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author

Evangelos Christodoulou

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Maxim Petoukhov

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

René H. Medema

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

J. Julian Blow

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Dmitri Svergun

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Stavros Taraviras

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Anastassis Perrakis

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

V De Marco

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

P J Gillespie

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

A Li

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

N Karantzelis

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

R Klompmaker

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

S van Gerwen

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

A Fish

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

M S Iliou

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Z Lygerou

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

language of work or name

English

0 references

publication date

11 November 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

12 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

106

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

issue

47

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

page(s)

19807-19812

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin

12 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Preventing re-replication of chromosomal DNA.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Functional domains of the Xenopus replication licensing factor Cdt1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Determination of domain structure of proteins from X-ray solution scattering

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Geminin, an inhibitor of DNA replication, is degraded during mitosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

DNA replication in eukaryotic cells

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

The Drosophila Geminin homolog: roles for Geminin in limiting DNA replication, in anaphase and in neurogenesis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Structural basis for inhibition of the replication licensing factor Cdt1 by geminin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

The APC/C inhibitor, Emi1, is essential for prevention of rereplication

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Cell cycle and developmental regulations of replication factors in mouse embryonic stem cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Regulation of early events in chromosome replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Geminin has dimerization, Cdt1-binding, and destruction domains that are required for biological activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

A p53-dependent checkpoint pathway prevents rereplication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Control of DNA replication licensing in a cell cycle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Regulation of geminin functions by cell cycle-dependent nuclear-cytoplasmic shuttling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775996

Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region.

2 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905281106

Dynamics of DNA binding of replication initiation proteins during de novo formation of pre-replicative complexes in Xenopus egg extracts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905281106

Cell cycle regulation of the licensing activity of Cdt1 in Xenopus laevis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905281106

Subcellular translocation signals regulate Geminin activity during embryonic development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905281106

Crystal structure of the coiled-coil dimerization motif of geminin: structural and functional insights on DNA replication regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905281106

Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905281106

Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905281106

PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19906994

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Recombinant Cdt1 induces rereplication of G2 nuclei in Xenopus egg extracts

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19906994

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0905281106

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

ADS bibcode

2009PNAS..10619807D

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906994%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

2 references