(Q5205796)

DNA (cytosine-5)-methyltransferase 1-like

1 reference

DNA (cytosine-5)-methyltransferase 1, replication foci domain, protein family

1 reference

Zinc finger, CXXC-type, protein family

1 reference

DMAP1-binding domain, protein family

1 reference

DNA methylase, C-5 cytosine-specific, active site, protein family

1 reference

DNA methylase, C-5 cytosine-specific, conserved site, protein family

1 reference

Bromo adjacent homology (BAH) domain, protein family

1 reference

2 references

13 November 2019

17 September 2016

2 references

13 November 2019

21 March 2016

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

4 references

17 October 2017

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

17 October 2017

CXXC domain of human DNMT1 is essential for enzymatic activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

promoter-specific chromatin binding

1 reference

8 April 2019

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

15 references

8 April 2019

SUMOylation enhances DNA methyltransferase 1 activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

UHRF1 plays a role in maintaining DNA methylation in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

The Polycomb group protein EZH2 directly controls DNA methylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

A Protein Interaction between β-Catenin and Dnmt1 Regulates Wnt Signaling and DNA Methylation in Colorectal Cancer Cells.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

DNA (cytosine-5-)-methyltransferase activity

5 references

17 October 2017

New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

17 October 2017

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

DNA-binding transcription factor activity, RNA polymerase II-specific

IDA

1 reference

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

CXXC domain of human DNMT1 is essential for enzymatic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

DNA (cytosine-5-)-methyltransferase activity

6 references

8 April 2019

New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

pericentric heterochromatin

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

5 references

17 October 2017

New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

17 October 2017

Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

6 references

8 April 2019

New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

C-5 methylation of cytosine

HDA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

regulation of transcription, DNA-templated

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

maintenance of DNA methylation

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

17 October 2017

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

17 October 2017

CXXC domain of human DNMT1 is essential for enzymatic activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

positive regulation of DNA methylation-dependent heterochromatin assembly

IDA

1 reference

8 April 2019

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

transcription, DNA-templated

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

positive regulation of gene expression

1 reference

8 April 2019

DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

negative regulation of gene expression, epigenetic

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

positive regulation of histone H3-K4 methylation

TAS

1 reference

8 April 2019

DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

negative regulation of histone H3-K9 methylation

1 reference

8 April 2019

DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

cellular response to amino acid stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

Ras protein signal transduction

1 reference

8 April 2019

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

negative regulation of transcription, DNA-templated

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

DNA methylation on cytosine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

DNA methylation involved in embryo development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

chromatin organization

1 reference

8 April 2019

maintenance of DNA methylation

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

CXXC domain of human DNMT1 is essential for enzymatic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

DNA methylation on cytosine within a CG sequence

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

negative regulation of gene expression

1 reference

8 April 2019

MiR-140-5p regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and differentiation by targeting Dnmt1 and promoting SOD2 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

positive regulation of vascular associated smooth muscle cell proliferation

1 reference

8 April 2019

MiR-140-5p regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and differentiation by targeting Dnmt1 and promoting SOD2 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

negative regulation of vascular associated smooth muscle cell apoptotic process

1 reference

8 April 2019

MiR-140-5p regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and differentiation by targeting Dnmt1 and promoting SOD2 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

1 reference

8 April 2019

MiR-140-5p regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and differentiation by targeting Dnmt1 and promoting SOD2 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358

physically interacts with

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201129

Gene Atlas image

PBB GE DNMT1 201697 s at fs.png
732 × 530; 12 KB

0 references

has part(s)

DMAP1-binding domain

1 reference

Zinc finger, CXXC-type

1 reference

Bromo adjacent homology (BAH) domain

1 reference

DNA methylase, C-5 cytosine-specific, active site

1 reference

DNA methylase, C-5 cytosine-specific, conserved site

1 reference

DNA (cytosine-5)-methyltransferase 1, replication foci domain

1 reference

D08.811.913.555.500.350.100.500.500

Identifiers

MeSH descriptor ID

D000076123

subject named as

DNA (Cytosine-5-)-Methyltransferase 1

0 references

MeSH tree code

0 references

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

21 March 2016

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference