(Q52070431)

English

Pharmacokinetic-pharmacodynamic modelling of tiagabine CNS effects upon chronic treatment in rats: lack of change in concentration-EEG effect relationship.

scientific article published in December 2000

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scholarly article

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11102742%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Pharmacokinetic-pharmacodynamic modelling of tiagabine CNS effects upon chronic treatment in rats: lack of change in concentration-EEG effect relationship (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11102742%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11102742%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

author name string

Altorf BA

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11102742%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Voskuyl RA

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11102742%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Danhof M

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11102742%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

language of work or name

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publication date

1 December 2000

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11102742%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

European Journal of Pharmaceutical Sciences

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11102742%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

12

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11102742%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11102742%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

141-150

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11102742%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

(R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Stereoselective central nervous system effects of the R- and S-isomers of the GABA uptake blocker N-(4, 4-di-(3-methylthien-2-yl)but-3-enyl) nipecotic acid in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of amygdala kindling on the central nervous system effects of tiagabine: EEG effects versus brain GABA levels.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Application of a combined "effect compartment/indirect response model" to the central nervous system effects of tiagabine in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism-based modeling of functional adaptation upon chronic treatment with midazolam.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

From GABAA receptor diversity emerges a unified vision of GABAergic inhibition.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition by Neuroleptics of Uptake of 3H-GABA into Rat Brain Synaptosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

High-performance liquid chromatographic procedure for the determination of tiagabine concentrations in human plasma using electrochemical detection

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Tolerance to the anticonvulsant effect of benzodiazepines

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Biochemical and behavioral studies following subchronic administration of GABA uptake inhibitors in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

GABA synaptic mechanisms: stereochemical and conformational requirements

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Electroencephalogram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration-EEG effect relationship

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Estimating impossible curves using NONMEM.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

GABAA receptors: ligand-gated Cl- ion channels modulated by multiple drug-binding sites

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The gamma-aminobutyric acid uptake inhibitor, tiagabine, is anticonvulsant in two animal models of reflex epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Lack of tolerance to the anticonvulsant effects of tiagabine following chronic (21 day) treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of chronic tiagabine treatment on [3H]GABAA, [3H]GABAB and [3H]tiagabine binding to sections from mice brain

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900179-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0928-0987(00)00179-2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11102742%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11102742%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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