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English
Morphine-3-glucuronide has a minor effect on morphine antinociception. Pharmacodynamic modeling.
scientific article published in July 1998
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9649348
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9649348%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
title
Morphine-3-glucuronide has a minor effect on morphine antinociception. Pharmacodynamic modeling
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9649348
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9649348%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
main subject
morphine
1 reference
based on heuristic
inferred from title
pharmacodynamics
1 reference
based on heuristic
inferred from title
author
Fredrik Jonsson
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9649348
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9649348%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
author name string
Gardmark M
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9649348
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9649348%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
Karlsson MO
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9649348
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9649348%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
Hammarlund-Udenaes M
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9649348
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9649348%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
language of work or name
English
0 references
publication date
1 July 1998
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9649348
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9649348%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
published in
Journal of Pharmaceutical Sciences
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9649348
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9649348%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
volume
87
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9649348
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9649348%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
issue
7
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9649348
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9649348%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
page(s)
813-820
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9649348
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9649348%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
cites work
Morphine-3-glucuronide may functionally antagonize morphine-6-glucuronide induced antinociception and ventilatory depression in the rat
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacokinetics and pharmacodynamics of morphine-3-glucuronide in rats and its influence on the antinociceptive effect of morphine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Relationship between morphine analgesia and cortical extracellular fluid levels of morphine and its metabolites in the rat: a microdialysis study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Morphine-3-glucuronide--a potent antagonist of morphine analgesia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intrathecal morphine-3-glucuronide does not antagonize spinal antinociception by morphine or morphine-6-glucuronide in rats.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lack of effect of morphine-3-glucuronide on the spinal antinociceptive actions of morphine in the rat: an electrophysiological study.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of prior morphine-3-glucuronide exposure on morphine disposition and antinociception
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Morphine-3-glucuronide: silent regulator of morphine actions.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Morphine derivatives with diminished opiate receptor potency show enhanced central excitatory activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antinociceptive and ventilatory effects of the morphine metabolites: morphine-6-glucuronide and morphine-3-glucuronide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The excitatory effects of morphine-3-glucuronide are attenuated by LY274614, a competitive NMDA receptor antagonist, and by midazolam, an agonist at the benzodiazepine site on the GABAA receptor complex.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Influence of renal function on the elimination of morphine and morphine glucuronides.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Morphine-6-glucuronide, a potent mu agonist.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhanced binding of morphine and nalorphine to opioid delta receptor by glucuronate and sulfate conjugations at the 6-position
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Morphine-6-glucuronide has high affinity for the opioid receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Analgesic Effect of Morphine Glucuronides
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The enantioselective glucuronidation of morphine in rats and humans. Evidence for the involvement of more than one UDP-glucuronosyltransferase isoenzyme
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Species differences in metabolism of codeine: urinary excretion of codeine glucuronide, morphine-3-glucuronide and morphine-6-glucuronide in mice, rats, guinea pigs and rabbits
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Species difference of site-selective glucuronidation of morphine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acute tolerance in morphine analgesia: continuous infusion and single injection in rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acute tolerance to narcotic analgesic drugs in rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential development of acute tolerance to analgesia, respiratory depression, gastrointestinal transit and hormone release in a morphine infusion model
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ventilatory effects of fourth cerebroventricular infusions of morphine-6- or morphine-3-glucuronide in the awake dog
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A pharmacokinetic-pharmacodynamic model of tolerance to morphine analgesia during infusion in rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An improved method for the simultaneous determination of morphine and its principal glucuronide metabolites
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Determination of morphine in serum and cerebrospinal fluid by gas chromatography and selected ion monitoring after reversed-phase column extraction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Effects of Caffeine and Theophylline on Nociceptive Stimulation in the Rat
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A MOLECULAR BASIS FOR DRUG ACTION.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of four basic models of indirect pharmacodynamic responses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Physiologic indirect response models characterize diverse types of pharmacodynamic effects
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mu receptor binding of some commonly used opioids and their metabolites
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacology of morphine and morphine-3-glucuronide at opioid, excitatory amino acid, GABA and glycine binding sites
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intrathecal high dose morphine produces hyperalgesia in the rat
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of morphine-3-glucuronide and morphine on the K+-evoked release of [3H]-glutamic acid and [14C]-gamma-aminobutyric acid from rat brain synaptosomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hot plate versus tail flick: evaluation of acute tolerance to continuous morphine infusion in the rat model
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oral morphine in cancer pain: influences on morphine and metabolite concentration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Concentrations of morphine, morphine-6-glucuronide and morphine-3-glucuronide in serum and cerebrospinal fluid following morphine administration to patients with morphine-resistant pain.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Plasma and cerebrospinal fluid concentrations of morphine and morphine glucuronides after oral morphine. The influence of renal failure.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kinetics of morphine in patients with renal failure
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The pharmacokinetics of morphine and morphine glucuronides in kidney failure
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Morphine and morphine metabolite concentrations in cerebrospinal fluid and plasma in cancer pain patients after slow-release oral morphine administration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hyperalgesia and myoclonus in terminal cancer patients treated with continuous intravenous morphine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disappearance of morphine-induced hyperalgesia after discontinuing or substituting morphine with other opioid agonists
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1021%2FJS980056F
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1021/JS980056F
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9649348
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9649348%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
PubMed publication ID
9649348
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9649348
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9649348%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
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