(Q52322708)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29651884%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

title

Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29651884%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Torpedo californica

1 reference

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29651884%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Rosanna Caliandro

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29651884%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Alessandro Pesaresi

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29651884%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Luca Cariati

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29651884%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Antonio Procopio

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29651884%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Manuela Oliverio

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29651884%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

author name string

Alessandro Pesaresi

2

1 reference

http://europepmc.org/abstract/PMC/6009889

19 July 2018

Luca Cariati

3

1 reference

http://europepmc.org/abstract/PMC/6009889

19 July 2018

Manuela Oliverio

5

1 reference

http://europepmc.org/abstract/PMC/6009889

19 July 2018

publication date

1 December 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29651884%20AND%20SRC:MED&resulttype=core&format=json

Journal of Enzyme Inhibition and Medicinal Chemistry

23 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29651884%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

volume

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29651884%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29651884%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

page(s)

794-803

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29651884%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

23 March 2020

copyright license

start time

1 January 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

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27 July 2018

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Synthesis of new donepezil analogues and investigation of their effects on cholinesterase enzymes

27 July 2018

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Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.

27 July 2018

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Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin

27 July 2018

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The pathophysiology of defective proteostasis in the hypothalamus - from obesity to ageing

27 July 2018

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Design, Synthesis, and Evaluation of Donepezil-Like Compounds as AChE and BACE-1 Inhibitors

27 July 2018

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Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer's Disease

27 July 2018

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The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex

27 July 2018

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Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease

27 July 2018

1 reference

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Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease

27 July 2018

1 reference

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Alzheimer mechanisms and therapeutic strategies

27 July 2018

1 reference

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REFMAC5 for the refinement of macromolecular crystal structures

27 July 2018

1 reference

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iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM

27 July 2018

1 reference

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Features and development of Coot

27 July 2018

1 reference

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Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.

27 July 2018

1 reference

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MolProbity: all-atom structure validation for macromolecular crystallography

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Phasercrystallographic software

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: a systematic review and meta-analysis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

The integration of macromolecular diffraction data

27 July 2018

1 reference

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Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent

27 July 2018

1 reference

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PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Insights into the ageing mind: a view from cognitive neuroscience

27 July 2018

1 reference

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The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development

27 July 2018

1 reference

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Cation-pi interactions in structural biology

27 July 2018

1 reference

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Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs

27 July 2018

1 reference

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Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A

27 July 2018

1 reference

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Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase

27 July 2018

1 reference

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Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine "bio-oxidizable" prodrugs: Synthesis, biological evaluation and structure-activity relationship.

27 July 2018

1 reference

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Rational Design and Multibiological Profiling of Novel Donepezil-Trolox Hybrids against Alzheimer's Disease, with Cholinergic, Antioxidant, Neuroprotective, and Cognition Enhancing Properties.

13 August 2018

1 reference

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BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease

13 August 2018

1 reference

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Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a "Bio-Oxidizable" Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation

13 August 2018

1 reference

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Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.

13 August 2018

1 reference

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Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Synthesis and pharmacological evaluation of donepezil-based agents as new cholinesterase/monoamine oxidase inhibitors for the potential application against Alzheimer's disease.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.

13 August 2018

1 reference

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Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine.

13 August 2018

1 reference

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Non-conventional methodologies in the synthesis of 1-indanones.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Overview of the CCP4 suite and current developments

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

A new commercially viable synthetic route for donepezil hydrochloride: anti-Alzheimer's drug

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Potent pyrrolidine- and piperidine-based BACE-1 inhibitors

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

A semiempirical free energy force field with charge-based desolvation

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

The significance of neuroinflammation in understanding Alzheimer's disease.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Free radicals and antioxidants in normal physiological functions and human disease

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Aromatic amino‐acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept®) to cholinesterases

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

A new and rapid colorimetric determination of acetylcholinesterase activity

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold

13 August 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

2 November 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica 1 1Edited by R. Huber

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Validation of protein models from Cα coordinates alone

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6009889

Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C

30 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29651884

12 December 2020

inferred from PubMed ID database lookup

A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29651884

12 December 2020

inferred from PubMed ID database lookup

Determining Partition Coefficient (Log P), Distribution Coefficient (Log D) and Ionization Constant (pKa) in Early Drug Discovery

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29651884

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1080/14756366.2018.1458030

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29651884%20AND%20SRC:MED&resulttype=core&format=json

release_re7futhdyrfzti2hrugoo3tnbm

23 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/re7futhdyrfzti2hrugoo3tnbm

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29651884%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

PubMed publication ID

29651884

1 reference