(Q52375973)

30 April 2018

title

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance. (English)

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30 April 2018

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Sarah Pickles

1

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30 April 2018

Pierre Vigié

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2

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30 April 2018

Richard J Youle

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3

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30 April 2018

language of work or name

English

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publication date

1 February 2018

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30 April 2018

published in

Current Biology

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30 April 2018

volume

28

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30 April 2018

issue

4

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30 April 2018

page(s)

R170-R185

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30 April 2018

The effects of hibernation on cone visual cells in the ground squirrel

cites work

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12 December 2020

Mitochondrial complex I deficiency in Parkinson's disease

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12 December 2020

Selective induction of mitochondrial chaperones in response to loss of the mitochondrial genome

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12 December 2020

Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3.

1 reference

12 December 2020

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

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12 December 2020

Ubiquitinated sperm mitochondria, selective proteolysis, and the regulation of mitochondrial inheritance in mammalian embryos.

1 reference

12 December 2020

cDNA Cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised rats

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12 December 2020

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

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12 December 2020

Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis

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12 December 2020

On the origin of mitosing cells

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12 December 2020

HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.

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12 December 2020

A mitochondrial specific stress response in mammalian cells

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12 December 2020

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1.

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12 December 2020

Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway

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12 December 2020

Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle

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12 December 2020

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

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12 December 2020

The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation

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12 December 2020

Premature ageing in mice expressing defective mitochondrial DNA polymerase

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12 December 2020

Uth1p is involved in the autophagic degradation of mitochondria

1 reference

12 December 2020

Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging

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12 December 2020

Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast

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12 December 2020

Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle

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12 December 2020

Phylogenomics of life-or-death switches in multicellular animals: Bcl-2, BH3-Only, and BNip families of apoptotic regulators

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12 December 2020

Nuclear respiratory factor 2 senses changing cellular energy demands and its silencing down-regulates cytochrome oxidase and other target gene mRNAs

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12 December 2020

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons.

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12 December 2020

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

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12 December 2020

Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy

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12 December 2020

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

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12 December 2020

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

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12 December 2020

Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response

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12 December 2020

A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics

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12 December 2020

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

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12 December 2020

Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis

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12 December 2020

BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy

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12 December 2020

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

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12 December 2020

Discovery of genes activated by the mitochondrial unfolded protein response (mtUPR) and cognate promoter elements

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12 December 2020

ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans

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12 December 2020

NIX is required for programmed mitochondrial clearance during reticulocyte maturation

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12 December 2020

PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle.

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12 December 2020

Nuclear respiratory factor 1 regulates all ten nuclear-encoded subunits of cytochrome c oxidase in neurons

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12 December 2020

Essential role for Nix in autophagic maturation of erythroid cells

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12 December 2020

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

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12 December 2020

Mitophagy in yeast occurs through a selective mechanism

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12 December 2020

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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12 December 2020

Nix directly binds to GABARAP: a possible crosstalk between apoptosis and autophagy

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12 December 2020

Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy

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12 December 2020

Atg32 is a mitochondrial protein that confers selectivity during mitophagy

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12 December 2020

The role of mitochondria in apoptosis*.

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12 December 2020

Autophagy-dependent and -independent mechanisms of mitochondrial clearance during reticulocyte maturation

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12 December 2020

Nix is a selective autophagy receptor for mitochondrial clearance

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12 December 2020

The role of the Atg1/ULK1 complex in autophagy regulation

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12 December 2020

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

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12 December 2020

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

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12 December 2020

p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

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12 December 2020

Analysis of proteome dynamics in the mouse brain

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12 December 2020

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

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12 December 2020

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

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12 December 2020

The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover

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12 December 2020

PINK1 cleavage at position A103 by the mitochondrial protease PARL.

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12 December 2020

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

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12 December 2020

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

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12 December 2020

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

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12 December 2020

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

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12 December 2020

TFEB links autophagy to lysosomal biogenesis

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12 December 2020

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

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12 December 2020

Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation

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12 December 2020

Phosphorylation of Serine 114 on Atg32 mediates mitophagy

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12 December 2020

Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

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12 December 2020

A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery

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12 December 2020

Degradation of paternal mitochondria by fertilization-triggered autophagy in C. elegans embryos.

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12 December 2020

Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission

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12 December 2020

A vesicular transport pathway shuttles cargo from mitochondria to lysosomes.

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12 December 2020

Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin

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12 December 2020

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12 December 2020

Barriers to male transmission of mitochondrial DNA in sperm development

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12 December 2020

Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number

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12 December 2020

Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy

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12 December 2020

Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.

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12 December 2020

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

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12 December 2020

PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.

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12 December 2020

A short linear motif in BNIP3L (NIX) mediates mitochondrial clearance in reticulocytes

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12 December 2020

Metabolic labeling reveals proteome dynamics of mouse mitochondria

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12 December 2020

Heteroplasmy of mouse mtDNA is genetically unstable and results in altered behavior and cognition

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12 December 2020

Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology

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12 December 2020

Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis

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12 December 2020

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

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12 December 2020

VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations

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12 December 2020

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

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12 December 2020

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

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12 December 2020

Erythropoiesis: development and differentiation

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12 December 2020

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

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12 December 2020

Mitochondrial degradation during starvation is selective and temporally distinct from bulk autophagy in yeast

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12 December 2020

Structure of parkin reveals mechanisms for ubiquitin ligase activation

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12 December 2020

Mitonuclear protein imbalance as a conserved longevity mechanism

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12 December 2020

Structure of the human Parkin ligase domain in an autoinhibited state

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12 December 2020

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

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12 December 2020

The scaffold protein Atg11 recruits fission machinery to drive selective mitochondria degradation by autophagy

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12 December 2020

Unique insights into maternal mitochondrial inheritance in mice

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12 December 2020

Dynamics of mitochondrial inheritance in the evolution of binary mating types and two sexes

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12 December 2020

Tissue- and cell-type-specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model.

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12 December 2020

Autophagy and mitophagy participate in ocular lens organelle degradation.

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12 December 2020

Bit-by-bit autophagic removal of parkin-labelled mitochondria

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12 December 2020

PINK1 is degraded through the N-end rule pathway

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12 December 2020

MitoTimer: a novel tool for monitoring mitochondrial turnover

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12 December 2020

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

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12 December 2020

A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment.

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12 December 2020

Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy

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12 December 2020

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

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12 December 2020

Stress-regulated translational attenuation adapts mitochondrial protein import through Tim17A degradation.

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12 December 2020

GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy

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12 December 2020

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control

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12 December 2020

Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

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12 December 2020

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

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12 December 2020

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

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12 December 2020

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.

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12 December 2020

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

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12 December 2020

Ubiquitin is phosphorylated by PINK1 to activate parkin

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12 December 2020

Paternal mitochondrial destruction after fertilization is mediated by a common endocytic and autophagic pathway in Drosophila.

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12 December 2020

Cargo recognition and trafficking in selective autophagy

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12 December 2020

Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes

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12 December 2020

MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin

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12 December 2020

Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease.

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12 December 2020

Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.

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12 December 2020

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

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12 December 2020

Parkin modulates heteroplasmy of truncated mtDNA in Caenorhabditis elegans

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12 December 2020

Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering

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12 December 2020

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

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12 December 2020

The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease

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12 December 2020

Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).

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12 December 2020

Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

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12 December 2020

Phosphorylated ubiquitin chain is the genuine Parkin receptor.

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12 December 2020

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12 December 2020

New roles for mitochondrial proteases in health, ageing and disease

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12 December 2020

TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation

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12 December 2020

Extreme-Depth Re-sequencing of Mitochondrial DNA Finds No Evidence of Paternal Transmission in Humans

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12 December 2020

Mechanism of phospho-ubiquitin-induced PARKIN activation

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12 December 2020

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

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12 December 2020

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

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12 December 2020

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5

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12 December 2020

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol.

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12 December 2020

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

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12 December 2020

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

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12 December 2020

Atypical mitochondrial inheritance patterns in eukaryotes

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12 December 2020

Measuring In Vivo Mitophagy

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12 December 2020

α-MHC MitoTimer mouse: In vivo mitochondrial turnover model reveals remarkable mitochondrial heterogeneity in the heart

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12 December 2020

Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

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12 December 2020

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

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12 December 2020

Selective sorting and destruction of mitochondrial membrane proteins in aged yeast.

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12 December 2020

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

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12 December 2020

Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy

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12 December 2020

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12 December 2020

Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization

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12 December 2020

Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation

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12 December 2020

Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans

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12 December 2020

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

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12 December 2020

mito-QC illuminates mitophagy and mitochondrial architecture in vivo

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12 December 2020

Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system.

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12 December 2020

Autophagy and ubiquitin-proteasome system contribute to sperm mitophagy after mammalian fertilization

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12 December 2020

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.

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12 December 2020

Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1.

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12 December 2020

Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation.

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12 December 2020

Prion-Like Polymerization in Immunity and Inflammation.

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12 December 2020

Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy

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12 December 2020

Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor.

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12 December 2020

Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism

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12 December 2020

Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity

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12 December 2020

Proteasomal and Autophagic Degradation Systems

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12 December 2020

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

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12 December 2020

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

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12 December 2020

Mitochondrial fission facilitates the selective mitophagy of protein aggregates.

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12 December 2020

10.1016/J.CUB.2018.01.004

Identifiers

DOI

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30 April 2018

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30 April 2018