(Q52578353)

English

Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells.

scientific article published on 12 April 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

head and neck squamous cell carcinoma

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Ikuko Takeda

1

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

Shin-Ichiro Maruya

2

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

Takashi Shirasaki

3

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

Hiroki Mizukami

4

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

Takenori Takahata

5

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

Jeffrey N Myers

6

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

Seiji Kakehata

7

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

Soroku Yagihashi

8

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

Hideichi Shinkawa

9

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

publication date

12 April 2007

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

98

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

6

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

890-899

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells

1 reference

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21 January 2018

Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas.

1 reference

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21 January 2018

Potent inhibition of small-cell lung cancer cell growth by simvastatin reveals selective functions of Ras isoforms in growth factor signalling

1 reference

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21 January 2018

In nasopharyngeal carcinoma cells, Epstein-Barr virus LMP1 interacts with galectin 9 in membrane raft elements resistant to simvastatin.

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Mevalonate promotes the growth of tumors derived from human cancer cells in vivo and stimulates proliferation in vitro with enhanced cyclin-dependent kinase-2 activity

1 reference

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21 January 2018

Integrin signaling

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00471.X

21 January 2018

Anoikis mechanisms

1 reference

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N-Myc overexpression leads to decreased beta1 integrin expression and increased apoptosis in human neuroblastoma cells

1 reference

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Hypersialylation of beta1 integrins, observed in colon adenocarcinoma, may contribute to cancer progression by up-regulating cell motility

1 reference

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21 January 2018

Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo

1 reference

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21 January 2018

Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma. Implication for therapeutic decision making

1 reference

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21 January 2018

Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells

1 reference

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21 January 2018

Integrin-mediated signals regulated by members of the rho family of GTPases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00471.X

21 January 2018

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00471.X

21 January 2018

Alpha 3 beta 1 integrin promotes keratinocyte cell survival through activation of a MEK/ERK signaling pathway

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00471.X

21 January 2018

Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00471.X

21 January 2018

Beta 1-integrin protects hepatoma cells from chemotherapy induced apoptosis via a mitogen-activated protein kinase dependent pathway

1 reference

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21 January 2018

Alternative splicing controls the mechanisms of FAK autophosphorylation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00471.X

21 January 2018

Cleavage of focal adhesion kinase by caspases during apoptosis

1 reference

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21 January 2018

Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells

1 reference

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21 January 2018

Cell attachment to the extracellular matrix induces proteasomal degradation of p21(CIP1) via Cdc42/Rac1 signaling

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00471.X

21 January 2018

Overexpression of extracellular-signal regulated kinases on oral squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00471.X

21 January 2018

Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00471.X

21 January 2018

Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00471.X

21 January 2018

3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitor, fluvastatin, as a novel agent for prophylaxis of renal cancer metastasis

1 reference

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21 January 2018

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00471.X

21 January 2018

Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00471.X

21 January 2018

Lovastatin induces apoptosis in a primitive neuroectodermal tumor cell line in association with RB down-regulation and loss of the G1 checkpoint

1 reference

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21 January 2018

Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: contribution to its anti-angiogenic effect

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21 January 2018

5-Fluorouracil: mechanisms of action and clinical strategies

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Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme

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Identifiers

10.1111/J.1349-7006.2007.00471.X

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 May 2018

http://europepmc.org/abstract/MED/17428261

ResearchGate publication ID

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