(Q52604210)

4 May 2018

title

A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor. (English)

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4 May 2018

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6

Gerhard Müller-Newen

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4 May 2018

author name string

Cécile Ancey

1

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4 May 2018

Andrea Küster

2

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4 May 2018

Serge Haan

3

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4 May 2018

Andreas Herrmann

4

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4 May 2018

Peter C Heinrich

5

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4 May 2018

language of work or name

English

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publication date

19 March 2003

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4 May 2018

Journal of Biological Chemistry

published in

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4 May 2018

volume

278

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issue

19

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4 May 2018

page(s)

16968-16972

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4 May 2018

Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Hematopoietic receptor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Receptor recognition by gp130 cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Molecular cloning and expression of an IL-6 signal transducer, gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Interleukin-6: structure-function relationships.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Structure of an extracellular gp130 cytokine receptor signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

The N-terminus of gp130 is critical for the formation of the high-affinity interleukin-6 receptor complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Biological activity of a novel nonpeptide antagonist to the interleukin-6 receptor 20S,21-epoxy-resibufogenin-3-formate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Cytokine traps: multi-component, high-affinity blockers of cytokine action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

Two different epitopes of the signal transducer gp130 sequentially cooperate on IL-6-induced receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300081200

21 January 2018

Identifiers

DOI

10.1074/JBC.C300081200

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4 May 2018

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4 May 2018