(Q52644144)

5 May 2018

5 references

31 July 2019

28 September 2019

15 December 2019

21 July 2020

27 September 2020

Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders. (English)

1 reference

5 May 2018

guanylate cyclase-coupled receptor

main subject

cell surface receptor

1 reference

31 July 2019

1 reference

28 September 2019

1 reference

15 December 2019

1 reference

functional gastrointestinal disorder

21 July 2020

1 reference

27 September 2020

2

Michael Camilleri

1 reference

5 May 2018

Scott A Waldman

1

1 reference

5 May 2018

language of work or name

English

0 references

publication date

21 March 2018

1 reference

5 May 2018

1 August 2018

5 references

31 July 2019

28 September 2019

15 December 2019

21 July 2020

27 September 2020

6 references

5 May 2018

Creative Commons Attribution-NonCommercial

31 July 2019

28 September 2019

15 December 2019

21 July 2020

27 September 2020

5 references

31 July 2019

28 September 2019

15 December 2019

21 July 2020

27 September 2020

Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine

1 reference

12 December 2020

Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli

1 reference

12 December 2020

Stimulation of intestinal Cl- transport by heat-stable enterotoxin: activation of cAMP-dependent protein kinase by cGMP

1 reference

12 December 2020

Guanylin: an endogenous activator of intestinal guanylate cyclase

1 reference

12 December 2020

Towards an understanding of the arginine-aspartate interaction.

1 reference

12 December 2020

Guanylyl cyclase is a heat-stable enterotoxin receptor

1 reference

12 December 2020

Two precursors of the heat-stable enterotoxin of Escherichia coli: evidence of extracellular processing

1 reference

12 December 2020

The immature rat small intestine exhibits an increased sensitivity and response to Escherichia coli heat-stable enterotoxin

1 reference

12 December 2020

Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase

1 reference

12 December 2020

Prouroguanylin and proguanylin: purification from colon, structure, and modulation of bioactivity by proteases

1 reference

12 December 2020

Regulation of intestinal uroguanylin/guanylin receptor-mediated responses by mucosal acidity

1 reference

12 December 2020

Signal transduction pathways via guanylin and uroguanylin in stomach and intestine.

1 reference

12 December 2020

Symptoms in chronic constipation

1 reference

12 December 2020

Disruption of the guanylyl cyclase-C gene leads to a paradoxical phenotype of viable but heat-stable enterotoxin-resistant mice

1 reference

12 December 2020

Synthesis, biological activity and isomerism of guanylate cyclase C-activating peptides guanylin and uroguanylin

1 reference

12 December 2020

Mice lacking the guanylyl cyclase C receptor are resistant to STa-induced intestinal secretion

1 reference

12 December 2020

One peptide, two topologies: structure and interconversion dynamics of human uroguanylin isomers

1 reference

12 December 2020

Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays

1 reference

12 December 2020

Regulation of intestinal gene expression by dietary zinc: induction of uroguanylin mRNA by zinc deficiency

1 reference

12 December 2020

Expression of GC-C, a receptor-guanylate cyclase, and its endogenous ligands uroguanylin and guanylin along the rostrocaudal axis of the intestine

1 reference

12 December 2020

Uroguanylin treatment suppresses polyp formation in the Apc(Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP

1 reference

12 December 2020

Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells.

1 reference

12 December 2020

Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation

1 reference

12 December 2020

Bacterial enterotoxins are associated with resistance to colon cancer.

1 reference

12 December 2020

Side chain contributions to the interconversion of the topological isomers of guanylin-like peptides

1 reference

12 December 2020

Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis.

1 reference

12 December 2020

Chronic constipation: a survey of the patient perspective

1 reference

12 December 2020

Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity

1 reference

12 December 2020

The paracrine hormone hypothesis of colorectal cancer.

1 reference

12 December 2020

Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine.

1 reference

12 December 2020

The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling.

1 reference

12 December 2020

Intestinal mucosal barrier function in health and disease

1 reference

12 December 2020

Receptor guanylyl cyclase C (GC-C): regulation and signal transduction

1 reference

12 December 2020

Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation

1 reference

12 December 2020

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

1 reference

12 December 2020

Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier

1 reference

12 December 2020

Murine guanylate cyclase C regulates colonic injury and inflammation

1 reference

12 December 2020

Two randomized trials of linaclotide for chronic constipation

1 reference

12 December 2020

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

1 reference

12 December 2020

Uroguanylin regulates net fluid secretion via the NHE2 isoform of the Na/H+ exchanger in an intestinal cellular model.

1 reference

12 December 2020

GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity

1 reference

12 December 2020

Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis

1 reference

12 December 2020

Familial diarrhea syndrome caused by an activating GUCY2C mutation.

1 reference

12 December 2020

Meconium ileus caused by mutations in GUCY2C, encoding the CFTR-activating guanylate cyclase 2C

1 reference

12 December 2020

Linaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety.

1 reference

12 December 2020

A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation

1 reference

12 December 2020

Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation

1 reference

12 December 2020

Peripheral mechanisms in irritable bowel syndrome

1 reference

12 December 2020

Plecanatide, an oral guanylate cyclase C agonist acting locally in the gastrointestinal tract, is safe and well-tolerated in single doses

1 reference

12 December 2020

Diarrheal disease constitutes one of the top two causes of mortality among young children in developing countries. Preface

1 reference

12 December 2020

FDA and EMA end points: which outcome end points should we use in clinical trials in patients with irritable bowel syndrome?

1 reference

12 December 2020

Gastrointestinal pain: unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation

1 reference

12 December 2020

Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate

1 reference

12 December 2020

Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen.

1 reference

12 December 2020

Guanylate cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitis

1 reference

12 December 2020

Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain

1 reference

12 December 2020

The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancer

1 reference

12 December 2020

Meconium ileus in a Lebanese family secondary to mutations in the GUCY2C gene

1 reference

12 December 2020

Investigation of pH and Temperature Profiles in the GI Tract of Fasted Human Subjects Using the Intellicap(®) System.

1 reference

12 December 2020

Guanylate cyclase C agonists: emerging gastrointestinal therapies and actions

1 reference

12 December 2020

The spectrum of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation: US survey assessing symptoms, care seeking, and disease burden

1 reference

12 December 2020

Emerging treatments in Neurogastroenterology: Perspectives of guanylyl cyclase C agonists use in functional gastrointestinal disorders and inflammatory bowel diseases

1 reference

12 December 2020

The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease

1 reference

12 December 2020

Congenital secretory diarrhoea caused by activating germline mutations in GUCY2C.

1 reference

12 December 2020

Inhibition of Heat-Stable Toxin-Induced Intestinal Salt and Water Secretion by a Novel Class of Guanylyl Cyclase C Inhibitors.

1 reference

12 December 2020

Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED).

1 reference

12 December 2020

MRP4 Modulation of the Guanylate Cyclase-C/cGMP Pathway: Effects on Linaclotide-Induced Electrolyte Secretion and cGMP Efflux

1 reference

12 December 2020

The Evolution of Stomach Acidity and Its Relevance to the Human Microbiome

1 reference

12 December 2020

Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea

1 reference

12 December 2020

Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis

1 reference

12 December 2020

Advancing treatment options for chronic idiopathic constipation

1 reference

12 December 2020

Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology

1 reference

12 December 2020

Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology

1 reference

12 December 2020

Constipation: Advances in Diagnosis and Treatment

1 reference

12 December 2020

Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis

1 reference

12 December 2020

Molecular Physiology of Membrane Guanylyl Cyclase Receptors

1 reference

12 December 2020

Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa

1 reference

12 December 2020

GUCY2C ligand replacement to prevent colorectal cancer.

1 reference

12 December 2020

Expression of guanylate cyclase-C, guanylin, and uroguanylin is downregulated proportionally to the ulcerative colitis disease activity index

1 reference

12 December 2020

Optimization of Quantitative PCR Methods for Enteropathogen Detection

1 reference

12 December 2020

Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins

1 reference

12 December 2020

A Randomized Phase III Clinical Trial of Plecanatide, a Uroguanylin Analog, in Patients With Chronic Idiopathic Constipation

1 reference

12 December 2020

Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention

1 reference

12 December 2020

Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease.

1 reference

12 December 2020

Low-Dose Linaclotide (72 μg) for Chronic Idiopathic Constipation: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial

1 reference

12 December 2020

Randomized clinical trial: efficacy and safety of plecanatide in the treatment of chronic idiopathic constipation.

1 reference

12 December 2020

Determining an optimal dose of linaclotide for use in Japanese patients with irritable bowel syndrome with constipation: A phase II randomized, double-blind, placebo-controlled study.

1 reference

12 December 2020

Efficacy and Tolerability of Guanylate Cyclase-C Agonists for Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation: A Systematic Review and Meta-Analysis.

1 reference

12 December 2020

10.1136/GUTJNL-2018-316029

Identifiers

DOI

1 reference

5 May 2018

PMC publication ID

6204952

0 references

1 reference

5 May 2018