(Q52644782)

3 July 2018

title

Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance. (English)

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3 July 2018

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7

Matthias Blüher

1 reference

3 July 2018

Devram S Ghorpade

1

1 reference

3 July 2018

Lale Ozcan

2

1 reference

3 July 2018

Ze Zheng

3

1 reference

3 July 2018

Sarah M Nicoloro

4

1 reference

3 July 2018

Yuefei Shen

5

1 reference

3 July 2018

Emily Chen

6

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3 July 2018

Michael P Czech

8

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3 July 2018

Ira Tabas

9

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3 July 2018

language of work or name

English

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publication date

21 March 2018

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3 July 2018

published in

Nature

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3 July 2018

volume

555

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3 July 2018

issue

7698

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3 July 2018

page(s)

673-677

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3 July 2018

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6021131/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nature26138

0 references

cites work

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Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?

3 July 2018

1 reference

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Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance

3 July 2018

1 reference

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Peptide- and Amine-Modified Glucan Particles for the Delivery of Therapeutic siRNA.

3 July 2018

1 reference

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Factor Xa induces pro-inflammatory cytokine expression in RAW 264.7 macrophages via protease-activated receptor-2 activation

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.

3 July 2018

1 reference

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A major role of insulin in promoting obesity-associated adipose tissue inflammation

3 July 2018

1 reference

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A randomized, double-blind, placebo-controlled, phase II clinical trial to investigate the efficacy and safety of oral DA-1229 in patients with type 2 diabetes mellitus who have inadequate glycaemic control with diet and exercise.

3 July 2018

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Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer

3 July 2018

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Selection and evaluation of clinically relevant AAV variants in a xenograft liver model

3 July 2018

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Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.

3 July 2018

1 reference

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Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice

3 July 2018

1 reference

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Stress-induced skeletal muscle Gadd45a expression reprograms myonuclei and causes muscle atrophy.

3 July 2018

1 reference

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Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity

3 July 2018

1 reference

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Alogliptin as an initial therapy in patients with newly diagnosed, drug naïve type 2 diabetes: a randomized, control trial

3 July 2018

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Inflammatory links between obesity and metabolic disease

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Dipeptidyl peptidase IV inhibitor sitagliptin reduces local inflammation in adipose tissue and in pancreatic islets of obese mice

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

NF-kappaB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Obesity is associated with macrophage accumulation in adipose tissue

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

The multifunctional or moonlighting protein CD26/DPPIV.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Isolation of adipose tissue immune cells

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Efficacy, safety and dose-response relationship of teneligliptin, a dipeptidyl peptidase-4 inhibitor, in Japanese patients with type 2 diabetes mellitus.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Plasma dipeptidyl peptidase 4 activity correlates with body mass index and the plasma adiponectin concentration in healthy young people.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Improved glycaemic control with dipeptidyl peptidase-4 inhibition in patients with type 2 diabetes: vildagliptin (LAF237) dose response

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Coagulation factor Xa stimulates interleukin-8 release in endothelial cells and mononuclear leukocytes: implications in acute myocardial infarction

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021131

Initiation of the extrinsic pathway of coagulation by human and rabbit alveolar macrophages: a kinetic study

13 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29562231

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Factor Xa induces cytokine production and expression of adhesion molecules by human umbilical vein endothelial cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29562231

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE26138

1 reference

3 July 2018

Dimensions Publication ID

0 references

1 reference

3 July 2018

PubMed publication ID

29562231

1 reference

3 July 2018