(Q52653879)

English

Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.

scientific article published on 6 March 2018

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 May 2018

http://europepmc.org/abstract/MED/29544147

Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element. (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 May 2018

http://europepmc.org/abstract/MED/29544147

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Kevin P. Battaile

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Gerald H Lushington

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Stanley Perlman

10

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Anushka C Galasiti Kankanamalage

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Vishnu C Damalanka

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Athri D Rathnayake

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Nurjahan Mehzabeen

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Scott Lovell

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Kyeong-Ok Chang

11

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

William C Groutas

12

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

publication date

6 March 2018

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Europe PubMed Central

PubMed publication ID

5 May 2018

http://europepmc.org/abstract/MED/29544147

European Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

150

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

334-346

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis.

1 reference

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29 September 2018

Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model

1 reference

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29 September 2018

Update on Human Rhinovirus and Coronavirus Infections

1 reference

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29 September 2018

SARS and MERS: recent insights into emerging coronaviruses

1 reference

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29 September 2018

Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5891363

29 September 2018

MERS-CoV vaccine candidates in development: The current landscape

1 reference

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29 September 2018

Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5891363

29 September 2018

Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5891363

29 September 2018

An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5891363

29 September 2018

Coronaviruses - drug discovery and therapeutic options.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5891363

29 September 2018

Middle East respiratory syndrome and severe acute respiratory syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5891363

29 September 2018

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5891363

29 September 2018

Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5891363

29 September 2018

Structures of the Middle East respiratory syndrome coronavirus 3C-like protease reveal insights into substrate specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5891363

29 September 2018

Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5891363

29 September 2018

Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure-activity relationships and biochemical, X-ray crystallographic, cell-based, and in vivo studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5891363

29 September 2018

Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5891363

29 September 2018

The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5891363

29 September 2018

Pathogenesis of Middle East respiratory syndrome coronavirus

1 reference

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29 September 2018

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5891363

29 September 2018

From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5891363

29 September 2018

Antiviral drugs specific for coronaviruses in preclinical development

1 reference

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29 September 2018

Coronaviruses: important emerging human pathogens

1 reference

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29 September 2018

Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation

1 reference

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29 September 2018

Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2.

1 reference

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29 September 2018

Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors

1 reference

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29 September 2018

Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses.

1 reference

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29 September 2018

Linking Crystallographic Model and Data Quality

1 reference

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29 September 2018

Towards automated crystallographic structure refinement with phenix.refine

1 reference

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29 September 2018

Data processing and analysis with the autoPROC toolbox

1 reference

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29 September 2018

An introduction to data reduction: space-group determination, scaling and intensity statistics

1 reference

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Features and development of Coot

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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29 September 2018

1 reference

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1 reference

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1 reference

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Scaling and assessment of data quality

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Developments in the CCP4 molecular-graphics project

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Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements

1 reference

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29 September 2018

Improved R-factors for diffraction data analysis in macromolecular crystallography

1 reference

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29 September 2018

On the size of the active site in proteases. I. Papain

1 reference

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29 September 2018

Biochemistry. Resolving some old problems in protein crystallography

1 reference

https://pubmed.ncbi.nlm.nih.gov/29544147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Middle East Respiratory Syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/29544147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correction: Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29544147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.EJMECH.2018.03.004

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29544147%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

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